Oncologist-approved cancer information from the American Society of Clinical Oncology
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Brain Tumor

This section has been reviewed and approved by the Cancer.Net Editorial Board, 6/2013
Latest Research

ON THIS PAGE: You will read about the scientific research being done now to learn more about brain tumors and how to treat them. To see other pages in this guide, use the colored boxes on the right side of your screen, or click “Next” at the bottom.

Doctors are working to learn more about brain tumors, ways to prevent them, how to best treat them, and how to provide the best care to people diagnosed with a brain tumor. The following areas of research may include new options for patients through clinical trials. Always talk with your doctor about the diagnostic and treatment options best for you.

Enhanced imaging tests. New techniques for imaging scans are being researched. These may help doctors better track how well treatment is working and watch for possible tumor recurrence or growth.

Biomarkers. Researchers are examining biomarkers to find better ways of using blood or other tests to determine the presence of a brain tumor before symptoms begin.

ImmunotherapyImmunotherapy, also called biologic therapy or biological response modifier (BRM) therapy, is designed to boost the body's natural defenses to fight the cancer. It uses materials either made by the body or in a laboratory to improve, target, or restore immune system function. Different methods are being studied for brain tumors, such as the use of dendritic cells or the use of vaccines aimed against a specific molecule on the surface of the tumor cells. Several methods are currently being tested in clinical trials.

Targeted therapy. As outlined in Treatment Options, this type of treatment targets faulty genes or proteins that contribute to cancer growth and development. Research continues on the use of therapies for brain tumors that target the different ways a tumor grows, how a tumor spreads, and how tumor cells die.

Blood-brain barrier disruption. This technique temporarily disrupts the brain’s natural protective barrier in order to allow chemotherapy to more easily enter the brain from the bloodstream.

New combination therapies.  New combinations may include radiation therapy and chemotherapy with a convection enhanced delivery (CED), which is a method to infuse drugs and other molecules directly into the tumor. CED allows chemotherapy to be delivered more safely and effectively by pumping the drug under pressure into the tumor cells. The drug links only to receptors located on tumor cells. By targeting the tumor cells, CED helps avoid damage to healthy brain cells and reduces the risk of side effects commonly found with the standard way chemotherapy is given.

New drugs and combinations of drugs. Researchers are looking at using drugs currently used for other types of cancer as treatment for a brain tumor. Combinations of drugs being studied for brain tumor treatment include temozolomide and bevacizumab. In addition, combinations of drugs that target different pathways a tumor uses to grow and spread are being explored. Since tumors can develop resistance to chemotherapy, meaning the treatment stops working, another approach is to use a treatment that targets how tumor cells develop resistance.

Gene therapy. This type of therapy seeks to replace or repair abnormal genes that are causing or helping tumor growth.

Genetic research. Researchers are seeking to learn more about mutations of specific genes and how they relate to the risk and growth of brain tumors. In particular, The Cancer Genome Atlas Research Network is a large, ongoing effort by the National Institutes of Health to find out more about the link between genetics and glioblastoma. Recent results include the discovery of three specific genetic mutations not previously linked to glioblastoma; the affected genes are NF1, ERBB2, and PIK3R1; other findings focused on the involvement of the MGMT gene and mutations of IDH gene. This information is useful to researchers and may eventually lead to advances in the diagnosis and treatment of this type of brain tumor. Learn more about cancer genome research.

Supportive care. Clinical trials are underway to find better ways of reducing symptoms and side effects of current brain tumor treatments, in order to improve patients’ comfort and quality of life.

Looking for More about the Latest Research?

If you would like additional information about the latest areas of research regarding brain tumors, explore these related items that take you outside of this guide:

To continue reading this guide, choose “Next” (below, right) to see a section about coping with the side effects of the disease or its treatment. Or, use the colored boxes located on the right side of your screen to visit any section.

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