Ewing Sarcoma - Childhood and Adolescence: Latest Research

Approved by the Cancer.Net Editorial Board, 08/2016

ON THIS PAGE: You will read about the scientific research being done now to learn more about this type of cancer and how to treat it. To see other pages, use the menu.

Doctors are working to learn more about Ewing sarcoma, how to best treat it, and how to provide the best care to children and teens diagnosed with this disease. The following areas of research may include new options for patients through clinical trials. Always talk with your child’s doctor about the diagnostic and treatment options best for your child.

  • New chemotherapy. Researchers are evaluating the use of cyclophosphamide, topotecan, and vincristine in addition to standard chemotherapy for patients with newly diagnosed, localized Ewing sarcoma.

  • Allogeneic stem cell transplantation. In an ALLO stem cell transplant (see Treatment Options for a description), the patient is treated with high doses of chemotherapy, radiation therapy, or both to destroy as many tumor cells as possible and to prevent the patient’s immune system from rejecting the donated stem cells. After the high-dose therapy is given, stem cells obtained from a healthy donor, usually a sibling, are infused into the patient's bloodstream. ALLO stem cell transplants combined with sirolimus (Rapamune) and other drugs have been shown to prevent the growth of Ewing cells in the laboratory.

  • Bilateral lung radiation. For all patients with disease that has spread to the lung, whole-lung radiation therapy should be considered, even if chemotherapy has removed most obvious signs of metastatic disease. During this treatment, radiation therapy is given to both lungs after the patient has completed chemotherapy. For some patients, autologous (AUTO) stem cell transplant is recommended but should only be done in a clinical trial.

  • Insulin-like growth factor receptor-1 (IGF-1R) antibodies. The IGF-1R is an important growth protein for sarcomas. Blocking its activity may be an effective new way to improve sarcoma treatment. This new type of treatment combined with chemotherapy is being studied for people newly diagnosed with metastatic Ewing sarcoma.

  • Palliative care. Clinical trials are underway to find better ways of reducing symptoms and side effects of current Ewing sarcoma treatments to improve patients’ comfort and quality of life.

Looking for More About the Latest Research?

If you would like additional information about the latest areas of research regarding Ewing sarcoma, explore these related items that will take you outside of this guide:

The next section in this guide is Coping with Treatment. It offers some guidance in how to cope with the physical, emotional, and social changes that cancer and its treatment can bring. Or, use the menu to choose another section to continue reading this guide.