ON THIS PAGE: You will read about the scientific research being done now to learn more about HCL and PLL and how to treat these types of leukemia. To see other pages in this guide, use the colored boxes on the right side of your screen, or click “Next” at the bottom.
Doctors are working to learn more about HCL and PLL, ways to prevent these types of leukemia, how to best treat each disease, and how to provide the best care to people diagnosed with HCL or PLL. The following areas of research may include new options for patients through clinical trials. Always talk with your doctor about the diagnostic and treatment options best for you.
Targeted therapy. New treatments are being tested in clinical trials, including those that use angiogenesis inhibitors and monoclonal antibodies. Angiogenesis inhibitors are focused on stopping angiogenesis, which is the process of making new blood vessels. As discussed in the Treatment Options section, BL22 and LMB-2 are monoclonal antibodies linked to toxins that are designed to attach to the surface proteins of leukemia cells. Doctors are using these and other monoclonal antibodies in clinical trials for people with HCL when other treatments no longer work. In addition, drugs that target the BRAF gene are being studied for refractory HCL. In the future, finding out whether this gene is mutated also may help diagnose HCL.
Lastly, ibrutinib is a new drug targeting an enzyme called Bruton’s tyrosine kinase, which helps B-cell leukemias and lymphomas grow. It is being studied for several B-cell disorders and clinical trials in PLL and HCL will be done as well.
Supportive care. Clinical trials are underway to find better ways of reducing symptoms and side effects of current treatments in order to improve patients’ comfort and quality of life.
Looking for More about the Latest Research?
If you would like additional information about the latest areas of research regarding leukemia, explore these related items that take you outside of this guide:
- To find clinical trials specific to your diagnosis, talk with your doctor or search online clinical trial databases now.
To continue reading this guide, choose “Next” (below, right) to see a section about coping with the side effects of the disease or its treatment. Or, use the colored boxes located on the right side of your screen to visit any section.