ON THIS PAGE: You will read about the scientific research being done now to learn more about CML and how to treat it. To see other pages in this guide, use the colored boxes on the right side of your screen, or click “Next” at the bottom.
Doctors are working to learn more about CML, ways to prevent it, how to best treat it, and how to provide the best care to people diagnosed with this disease. The following areas of research may include new options for patients through clinical trials. Most cancer centers are actively involved in clinical trials aimed at increasing the number of people who are cured of CML. Always talk with your doctor about the diagnostic and treatment options best for you.
Improving current treatments. Research focused on increasing the effectiveness of CML treatments are listed below:
- Combining imatinib with other drugs, including low-dose cytarabine (Cytosar-U), interferon, or other BCR-ABL inhibitors
- Creating vaccines against BCR-ABL
- Developing newer methods of stem cell transplantation aimed at decreasing the side effects
- Evaluating other new TKIs for CML that does not respond to imatinib
- Safely stopping TKIs without the CML coming back.
Treatment to target remaining CML cells. Several laboratory studies are focused on possible treatments that may help destroy the few remaining CML cells in most patients who have received TKIs so they can stop medical treatment. One method uses inhibitors of a protein called “smoothened” made by the SMO gene in combination with BCR-ABL TKIs.
Supportive care. Clinical trials are underway to find better ways of reducing symptoms and side effects of current CML treatments in order to improve patients’ comfort and quality of life.
Looking for More about the Latest Research?
If you would like additional information about the latest areas of research regarding CML, explore these related items that take you outside of this guide:
- To find clinical trials specific to your diagnosis, talk with your doctor or search online clinical trial databases now.
- Review research announced at recent scientific meetings or in ASCO’s peer-reviewed journals.
- Visit ASCO’s CancerProgress.Net website to learn more about the historical pace of research for leukemia. Please note that this link takes you to a separate ASCO website.
To continue reading this guide, choose “Next” (below, right) to see a section about coping with the side effects of the disease or its treatment. Or, use the colored boxes located on the right side of your screen to visit any section.