Leukemia - Chronic T-Cell Lymphocytic: Overview

Approved by the Cancer.Net Editorial Board, 09/2015

ON THIS PAGE: You will find some basic information about this disease and the parts of the body it may affect. This is the first page of Cancer.Net’s Guide to Chronic T-Cell Leukemia. To see other pages, use the menu on the side of your screen. Think of that menu as a roadmap to this full guide.

Leukemia is a cancer of the blood cells. Leukemia begins when healthy blood cells change and grow uncontrollably.

About blood cells

Blood cells are made in the bone marrow, the spongy tissue inside the larger bones in the body. Changes in the bone marrow cells can cause too many or too few of certain blood cells. There are different types of blood cells:

  • Red blood cells that carry oxygen throughout the body

  • White blood cells that fight infection

  • Platelets that help the blood to clot

About leukemia

Types of leukemia are named after the specific blood cell that becomes cancerous, such as the lymphoid cells, which are a type of white blood cell, or the myeloid cells, which are bone marrow cells that turn into cells that fight bacterial infections.

There are four main types of leukemia in adults:

There are also less common types of leukemia, but they are generally subcategories of one of the four main categories listed above. This section focuses on different types of chronic T-cell lymphocytic leukemia, a subtype of chronic lymphocytic leukemia (CLL).

A T cell is a type of white blood cell that directly helps body’s immune system fight infection.

Subtypes of T-cell leukemia

The subtypes of T-cell leukemia include:

  • Large granular lymphocytic leukemia (LGLL). LGLL is a slow-growing T-cell leukemia and is more common in women than in men. The cause of LGLL is unknown. However, about 30% of people with LGLL also have rheumatoid arthritis, a chronic disease causing swelling in the joints of the hands, feet, wrists, knees, hips, or shoulders. Also, nearly half of patients with LGLL have a genetic change in either a gene called STAT3 or another called STAT5B.

  • T-cell prolymphocytic leukemia (T-PLL). T-PLL is an aggressive subtype of CLL. It is the most common mature T-cell leukemia in adults. T-PLL is more common in older men, but women may also develop T-PLL. It can affect the skin, but in a different way than Sezary syndrome (see below). Patients with T-PLL often have a change to the their T-cells called a T-cell receptor rearrangement, which is linked to abnormal T-cell growth.

  • Adult T-cell leukemia/lymphoma (ATLL). ATLL has four subtypes. Depending on the different features, it is subclassified as smoldering, chronic, acute, or adult T-cell lymphoma, which is a cancer of the lymph system. The acute and the adult T-cell lymphoma subtypes grow quickly. ATLL is caused by a retrovirus called the human T-cell leukemia virus (HTLV1).

  • Sezary syndrome. Sezary syndrome is a form of mycosis fungoides, a T-cell lymphoma that occurs in the skin. Sezary syndrome is usually slow-growing and takes years to develop from mycosis fungoides, which is located only on the skin. Sezary syndrome is generally diagnosed when large numbers of the lymphoma cells are found in the blood, often together with reddening of the skin, which is called erythroderma.

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