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Leukemia - Eosinophilic - Overview

This section has been reviewed and approved by the Cancer.Net Editorial Board, 06/2014

ON THIS PAGE: You will find some basic information about this disease and the parts of the body it may affect. This is the first page of Cancer.Net’s Guide to Eosinophilic Leukemia. To see other pages, use the menu on the side of your screen. Think of that menu as a roadmap to this full guide.

About leukemia

Leukemia is a cancer of the blood cells. Leukemia begins when normal blood cells change and grow uncontrollably. Blood cells are produced in the bone marrow, the spongy tissue inside the larger bones in the body. There are different types of blood cells, including red blood cells that carry oxygen throughout the body, white cells that fight infection, and platelets that help the blood to clot. Abnormal changes in the bone marrow cells can cause too many or too few of certain blood cells. There are four main types of leukemia in adults:

About eosinophilic leukemia

Eosinophilia is a condition that develops when the bone marrow makes too many eosinophils, a type of white blood cell. People can have many eosinophils without having leukemia. For example, sometimes the body makes too many eosinophils because of an allergy or an infection with a parasite. This type of eosinophilia is called secondary eosinophilia and is much more common than eosinophilic leukemia.

Chronic eosinophilic leukemia is a subtype of clonal eosinophilia, meaning it is caused by a new genetic mutation or change in the blood cells. It is sometimes called hypereosinophilic syndrome (HES). This disease is classified as a myeloproliferative disorder. Myelo- means bone marrow and proliferative means too much blood cell growth.

This section focuses on chronic eosinophilic leukemia. Acute eosinophilic leukemia is very rare and is treated similarly to acute myeloid leukemia (AML)

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Leukemia - Eosinophilic - Statistics

This section has been reviewed and approved by the Cancer.Net Editorial Board, 06/2014

ON THIS PAGE: You will find information about how many people learn they have this type of cancer each year and some general survival information. Remember, survival rates depend on several factors. To see other pages, use the menu on the side of your screen.

Eosinophilic leukemia is rare; no specific statistics are available. 

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Leukemia - Eosinophilic - Risk Factors

This section has been reviewed and approved by the Cancer.Net Editorial Board, 06/2014

ON THIS PAGE: You will find out more about the factors that increase the chance of developing eosinophilic leukemia. To see other pages, use the menu on the side of your screen.

A risk factor is anything that increases a person’s chance of developing cancer. Although risk factors often influence the development of leukemia, most do not directly cause leukemia. Some people with several risk factors never develop leukemia, while others with no known risk factors do. However, knowing your risk factors and talking about them with your doctor may help you make more informed lifestyle and health care choices.

Eosinophilic leukemia can very rarely be caused by a genetic mutation that develops during a person’s life because of environmental factors, smoking, and chemical or radiation exposure. However, no specific cause can be found for most patients with eosinophilic leukemia.

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Leukemia - Eosinophilic - Symptoms and Signs

This section has been reviewed and approved by the Cancer.Net Editorial Board, 06/2014

ON THIS PAGE: You will find out more about body changes and other things that can signal a problem that may need medical care. To see other pages, use the menu on the side of your screen. 

People with eosinophilic leukemia may experience the following symptoms or signs. Sometimes, people with eosinophilic leukemia do not show any of these symptoms. Or, these symptoms may be caused by a medical condition that is not leukemia.

  • Fever
  • Unexplained fatigue or shortness of breath
  • Cough
  • Swollen lymph nodes
  • Muscle pains
  • Itching
  • Diarrhea

If you are concerned about one or more of the symptoms or signs on this list, please talk with your doctor. Your doctor will ask how long and how often you’ve been experiencing the symptom(s), in addition to other questions. This is to help find out the cause of the problem, called a diagnosis.

If eosinophilic leukemia is diagnosed, relieving symptoms remains an important part of care and treatment. This may also be called symptom management, palliative care, or supportive care. Be sure to talk with your health care team about symptoms you experience, including any new symptoms or a change in symptoms.

The next section helps explain what tests and scans may be needed to learn more about the cause of the symptoms. Use the menu on the side of your screen to select Diagnosis, or you can select another section, to continue reading this guide.

Leukemia - Eosinophilic - Diagnosis

This section has been reviewed and approved by the Cancer.Net Editorial Board, 06/2014

ON THIS PAGE: You will find a list of the common tests, procedures, and scans that doctors can use to find out what’s wrong and identify the cause of the problem. To see other pages, use the menu on the side of your screen.

Doctors use many tests to diagnose eosinophilia. Although a patient’s signs and symptoms may cause a doctor to suspect eosinophilic leukemia, it is diagnosed only by testing a patient’s blood and bone marrow. Some tests may also help doctors decide which treatments may be the most effective. This list describes options for diagnosing eosinophilic leukemia, and not all tests listed will be used for every person. Your doctor may consider these factors when choosing a diagnostic test:

  • Age and medical condition
  • Type of leukemia suspected
  • Signs and symptoms
  • Previous test results

The main criteria for diagnosing eosinophilic leukemia are:

  • An eosinophil count in the blood of 1.5 x 109 /L or higher that lasts over time
  • No parasitic infection, allergic reaction, or other causes of eosinophilia
  • Problems with the functioning of a person’s organs because of the eosinophilia

In addition to a physical examination, the following tests may be used to diagnose eosinophilic leukemia:

Blood tests. The diagnosis of eosinophilic leukemia begins with a test called a complete blood count (CBC). A CBC measures the number of different types of cells in a person's blood. If the blood contains many eosinophils (see criteria above), eosinophilic leukemia is suspected.

Bone marrow aspiration and biopsy. These two procedures are similar and often done at the same time to examine the bone marrow. Bone marrow has both a solid and liquid part. A bone marrow aspiration removes a sample of fluid with a needle. A bone marrow biopsy is the removal of a small amount of solid tissue using a needle. The sample(s) are then analyzed by a pathologist to determine the number and type of abnormal cells. A pathologist is a doctor who specializes in interpreting laboratory tests and evaluating cells, tissues, and organs to diagnose disease. A common site for a bone marrow aspiration and biopsy is the pelvic bone, which is located in the lower back by the hip. The skin in that area is usually numbed with medication beforehand, and other types of anesthesia (medication to block awareness of pain) may be used.

Many immature cells, called blasts, in the bone marrow are a sign of acute rather than chronic eosinophilic leukemia. Acute eosinophilic leukemia is not covered in this article and is treated similarly to AML.

Molecular testing. Your doctor may recommend running laboratory tests on the eosinophils to identify specific genes, proteins, and other factors unique to the leukemia. If many eosinophils are found, a molecular genetic analysis should be done to test for a mutation that makes an abnormal protein known as FIP1-like-1/platelet-derived growth factor alpha. Immunophenotyping is the examination of the proteins on the surface of the leukemia cells and helps the doctor confirm the exact type of leukemia. Cytogenetics is the examination of the leukemia cells for abnormalities in the long strands of genes called chromosomes. It also helps the doctor confirm the diagnosis and may help to determine the person’s chance of recovery. Results of these tests will also help decide whether your treatment options include a type of treatment called targeted therapy (see Treatment Options).

Computed tomography (CT or CAT) scan. A CT scan creates a three-dimensional picture of the inside of the body with an x-ray machine. A computer then combines these images into a detailed, cross-sectional view that shows any abnormalities or tumors. A CT scan also shows enlarged lymph nodes or a swollen spleen or liver, and can be used to measure the size of these organs. Sometimes, a special dye called a contrast medium is given before the scan to provide better detail on the image. This dye can be injected into a patient’s vein or given as a pill to swallow.

Evaluation of the heart. People who have many eosinophils for a long period of time often have problems with heart function and rhythm. The doctor may recommend an electrocardiogram (ECG or EKG) and/or an echocardiogram (ECHO). An EKG is a noninvasive test that looks for abnormal heart rhythms or heart damage. An ECHO is a noninvasive test that looks at the structure and function of the heart using sound waves and an electronic sensor.

After diagnostic tests are done, your doctor will review all of the results with you. If the diagnosis is eosinophilic leukemia, these results also help the doctor describe the disease.

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Leukemia - Eosinophilic - Stages

This section has been reviewed and approved by the Cancer.Net Editorial Board, 06/2014

ON THIS PAGE: You will learn about how doctors usually describe the growth or spread of most cancers, called the stage, and how this differs for eosinophilic leukemia. To see other pages, use the menu on the side of your screen.

Generally, staging is a way of describing where a cancer is located, if or where it has spread, and whether it is affecting other parts of the body. Unlike most solid tumors, eosinophilic leukemia does not have a formal staging system. However, doctors still use diagnostic tests, such as those discussed in the Diagnosis section, to evaluate eosinophilic leukemia to help decide what kind of treatment is best and predict your prognosis, which is the chance of recovery.

Regular blood tests are the main ways to monitor a person’s recovery from eosinophilic leukemia, including any symptoms related to the disease and the number of immature cells in the bone marrow. Talk with your doctor for more details on how your specific type of leukemia will be evaluated.

The next section helps explain the treatment options for this type of leukemia. Use the menu on the side of your screen to select Treatment Options, or you can select another section, to continue reading this guide.

Leukemia - Eosinophilic - Treatment Options

This section has been reviewed and approved by the Cancer.Net Editorial Board, 06/2014

ON THIS PAGE: You will learn about the different ways doctors use to treat people with eosinophilic leukemia. To see other pages, use the menu on the side of your screen.

This section outlines treatments that are the standard of care (the best proven treatments available) for this specific type of leukemia. When making treatment plan decisions, patients are also encouraged to consider clinical trials as an option. A clinical trial is a research study to test a new approach to treatment to evaluate whether it is safe, effective, and possibly better than the standard treatment. Clinical trials may test such approaches as a new drug, a new combination of standard treatments, or new doses of current therapies. Your doctor can help you review all treatment options. For more information, see the Clinical Trials and Latest Research sections.

Treatment overview

For leukemia, different types of doctors often work together to create a patient’s overall treatment plan that combines different types of treatments. This is called a multidisciplinary team.

According to the National Cancer Institute, the best treatment for eosinophilic leukemia remains unclear. As explained in the Overview, eosinophilic leukemia is classified as a myeloproliferative disorder. Descriptions of the most common treatment options for a myeloproliferative disorder are listed below. Treatment options and recommendations depend on several factors, including the type of leukemia, possible side effects, and the patient’s preferences and overall health. Usually, myeloproliferative disorders cannot be cured, but there is often effective treatment to control the symptoms over the long term. This will be an important part of your care plan. Take time to learn about all of your treatment options and be sure to ask questions about things that are unclear. Also, talk about the goals of each treatment with your doctor and what you can expect while receiving the treatment. Learn more about making treatment decisions.

Chemotherapy

Chemotherapy is the use of drugs to destroy cancer cells, usually by stopping the cancer cells’ ability to grow and divide. Chemotherapy is given by a medical oncologist, a doctor who specializes in treating cancer with medication, or a hematologist, a doctor who specializes in treating blood disorders.

Systemic chemotherapy is delivered through the bloodstream to reach cancer cells throughout the body. Common ways to give chemotherapy include an intravenous (IV) tube placed into a vein using a needle or in a pill or capsule that is swallowed (orally). A chemotherapy regimen (schedule) usually consists of a specific number of cycles given over a set period of time. A patient may receive one drug at a time or combinations of different drugs at the same time.

Chemotherapy used to treat eosinophilic leukemia includes hydroxyurea (Droxia, Hydrea), cyclophosphamide (Neosar), corticosteroids such as prednisone (multiple brand names), and vincristine (Vincasar).

The side effects of chemotherapy depend on the individual and the dose used, but they can include fatigue, risk of infection, nausea and vomiting, hair loss, loss of appetite, and diarrhea. These side effects usually go away once treatment is finished.

Learn more about chemotherapy and preparing for treatment. The medications used to treat cancer are continually being evaluated. Talking with your doctor is often the best way to learn about the medications prescribed for you, their purpose, and their potential side effects or interactions with other medications. Learn more about your prescriptions by using searchable drug databases.

Surgery

Surgery to remove the spleen, which also makes white blood cells, is called a splenectomy. This operation may be recommended for some patients. A surgical oncologist is a doctor who specializes in treating cancer using surgery.  Learn more about surgery.

Immunotherapy

Immunotherapy, also called biologic therapy, is designed to boost the body's natural defenses to fight the leukemia. It uses materials made either by the body or in a laboratory to improve, target, or restore immune system function. Recombinant interferon alpha (Alferon, Intron A, Roferon-A) is a biologic therapy that is occasionally used to treat eosinophilic leukemia. Learn more about immunotherapy.

Targeted therapy

Targeted therapy is a treatment that targets the leukemia’s specific genes, proteins, or the tissue environment that contributes to leukemia growth and survival. This type of treatment blocks the growth and spread of leukemia cells while limiting damage to healthy cells.

Recent studies show that not all cancers have the same targets. To find the most effective treatment, your doctor may run tests to identify the genes, proteins, and other factors involved in your leukemia. As a result, doctors can better match each patient with the most effective treatment whenever possible. In addition, many research studies are taking place now to find out more about specific molecular targets and new treatments directed at them. Learn more about targeted treatments.

In many patients with hypereosinophilic syndrome, the leukemia cells have a specific genetic change that makes an abnormal protein called the FIP1-like-1/platelet-derived growth factor alpha. This abnormal protein stimulates the cells to grow.

Imatinib (Gleevec) is a drug that stops enzymes called tyrosine kinases from working and can destroy abnormal eosinophils by blocking the effect of the FIP1-like-1-platelet-derived growth factor alpha protein. Imatinib is more likely to work for patients who have this mutation; however, if a patient does not have this mutation, there is still a possibility that the drug will work. For many patients, imatinib can improve blood counts and symptoms very quickly and for many years if the drug is taken on a regular basis.

The main side effects of imatinib include swelling around the eyes, leg swelling, muscle cramping, headache, fatigue, rash, and joint pain. If this treatment works, it is often continued throughout a person’s lifetime. Talk with your doctor about possible side effects for a specific medication and how they can be managed.

Stem cell transplantation

A stem cell transplant is a medical procedure in which bone marrow that contains cancer is replaced by highly specialized cells, called hematopoietic stem cells, that develop into healthy bone marrow. Hematopoietic stem cells are blood-forming cells found both in the bloodstream and in the bone marrow. Today, this procedure is more commonly called a stem cell transplant, rather than bone marrow transplant, because it is the stem cells in the blood that are typically being transplanted, not the actual bone marrow tissue.

Before recommending transplantation, doctors will talk with the patient about the risks of this treatment and consider several other factors, such as the type of leukemia, results of any previous treatment, and the patient’s age and general health.

Transplantation is a higher-risk treatment and is not used often for people with eosinophilic leukemia because it is not always effective for this disease and because many patients with this disease are older and the risks of the procedure are higher.

There are two types of stem cell transplantation depending on the source of the replacement blood stem cells: allogeneic (ALLO) and autologous (AUTO). ALLO uses donated stem cells, while AUTO uses the patient’s own stem cells. In both types, the goal is to destroy all of the leukemia cells in the marrow, blood, and other parts of the body using high doses of chemotherapy and/or radiation therapy and then allow replacement blood stem cells to create healthy bone marrow. Learn more about stem cell and bone marrow transplantation

Getting care for symptoms and side effects

Leukemia and its treatment often cause side effects. In addition to treatment to slow, stop, or eliminate the disease, an important part of care is relieving a person’s symptoms and side effects. This approach is called palliative or supportive care, and it includes supporting the patient with his or her physical, emotional, and social needs.

Palliative care can help a person at any stage of illness. People often receive treatment for the leukemia and treatment to ease side effects at the same time. In fact, patients who receive both often have less severe symptoms, better quality of life, and report they are more satisfied with treatment.

Palliative treatments vary widely and often include medication, nutritional changes, relaxation techniques, and other therapies. You may also receive palliative treatments similar to those meant to eliminate the leukemia, such as chemotherapy and surgery. Talk with your doctor about the goals of each treatment in the treatment plan. Palliative care for eosinophilic leukemia may include the following treatments:

Steroids. Steroid medications are used to control some symptoms of eosinophilic leukemia.

Radiation therapy. Radiation therapy is the use of high-energy x-rays or other particles to destroy cancer cells. A doctor who specializes in giving radiation therapy to treat cancer is called a radiation oncologist. The most common type of radiation therapy is called external-beam radiation therapy, which is radiation given from a machine outside the body. When radiation therapy is given using implants, it is called internal radiation therapy or brachytherapy. A radiation therapy regimen (schedule) usually consists of a specific number of treatments given over a set period of time. Side effects from radiation therapy include fatigue, mild skin reactions, upset stomach, and loose bowel movements. Most side effects go away soon after treatment is finished.  Learn more about radiation therapy.

Before treatment begins, talk with your health care team about the possible side effects of your specific treatment plan and supportive care options. And during and after treatment, be sure to tell your doctor or another health care team member if you are experiencing a problem so it is addressed as quickly as possible. Learn more about palliative care.   

Refractory eosinophilic leukemia

If the leukemia continues to worsen despite treatment, it is called refractory leukemia. Patients with this diagnosis are encouraged to talk with doctors who are experienced in treating this type of leukemia, because there can be different opinions about the best treatment plan. Learn more about seeking a second opinion before starting treatment, so you are comfortable with the treatment plan chosen. This discussion may include clinical trials studying new treatments.

Your doctor may recommend a treatment plan that includes a combination of the treatments discussed above, such as chemotherapy, targeted therapy, immunotherapy, and bone marrow/stem cell transplantation. Supportive care will also be important to help relieve symptoms and side effects.

For most patients, a diagnosis of refractory leukemia is very stressful and, at times, difficult to bear. Patients and their families are encouraged to talk about the way they are feeling with doctors, nurses, social workers, or other members of the health care team. It may also be helpful to talk with other patients, including through a support group.

Remission and the chance of recurrence

A remission is when leukemia cannot be detected in the body and there are no symptoms. This may also be called “no evidence of disease” or NED. 

A remission can be temporary or permanent. This uncertainty leads to many survivors feeling worried or anxious that the leukemia will come back. While many remissions are permanent, it’s important to talk with your doctor about the possibility of the leukemia returning. Understanding the risk of recurrence and the treatment options may help you feel more prepared if the disease does return. Learn more about coping with the fear of recurrence.

If the leukemia does return after the original treatment, it is called recurrent leukemia. When this occurs, a cycle of testing will begin again to learn as much as possible about the recurrence. After testing is done, you and your doctor will talk about your treatment options. Often the treatment plan will include the therapies described above such as chemotherapy, immunotherapy, targeted therapy, and stem cell transplantation, but they may be used in a different combination or given at a different pace. Your doctor may also suggest clinical trials that are studying new ways to treat this type of recurrent leukemia.

People with recurrent leukemia often experience emotions such as disbelief or fear. Patients are encouraged to talk with their health care team about these feelings and ask about support services to help them cope. Learn more about dealing with cancer recurrence.

If treatment fails

Recovery from leukemia is not always possible. If treatment is not successful, the disease may be called advanced or terminal leukemia.

This diagnosis is stressful, and this is difficult to discuss for many people. However, it is important to have open and honest conversations with your doctor and health care team to express your feelings, preferences, and concerns. The health care team is there to help, and many team members have special skills, experience, and knowledge to support patients and their families. Making sure a person is physically comfortable and free from pain is extremely important.

Patients who have advanced leukemia and who are expected to live less than six months may want to consider a type of palliative care called hospice care. Hospice care is designed to provide the best possible quality of life for people who are near the end of life. You and your family are encouraged to think about where you would be most comfortable: at home, in the hospital, or in a hospice environment. Nursing care and special equipment can make staying at home a workable alternative for many families. Learn more about advanced cancer care planning.

After the death of a loved one, many people need support to help them cope with the loss. Learn more about grief and loss.

The next section helps explain clinical trials, which are research studies. Use the menu on the side of your screen to select About Clinical Trials, or you can select another section, to continue reading this guide.

Leukemia - Eosinophilic - About Clinical Trials

This section has been reviewed and approved by the Cancer.Net Editorial Board, 06/2014

ON THIS PAGE: You will learn more about clinical trials, which are the main way that new medical approaches are tested to see how well they work. To see other pages, use the menu on the side of your screen.

Doctors and scientists are always looking for better ways to treat patients with eosinophilic leukemia. To make scientific advances, doctors create research studies involving volunteers, called clinical trials.

Many clinical trials are focused on new treatments, evaluating whether a new treatment is safe, effective, and possibly better than the current (standard) treatment. These types of studies evaluate new drugs, different combinations of existing treatments, new approaches to radiation therapy or surgery, and new methods of treatment. Patients who participate in clinical trials are often among the first to receive new treatments before they are widely available. However, there is no guarantee that the new treatment will be safe, effective, or better than a standard treatment.

There are also clinical trials that study new ways to ease symptoms and side effects during treatment and manage the late effects that may occur after treatment. Talk with your doctor about clinical trials regarding side effects. In addition, there are ongoing studies about ways to prevent the disease.

Patients decide to participate in clinical trials for many reasons. For some patients, a clinical trial is the best treatment option available. Because standard treatments are not perfect, patients are often willing to face the added uncertainty of a clinical trial in the hope of a better result. Other patients volunteer for clinical trials because they know that these studies are the only way to make progress in treating eosinophilic leukemia. Even if they do not benefit directly from the clinical trial, their participation may benefit patients with eosinophilic leukemia in the future.

Sometimes people have concerns that, by participating in a clinical trial, they may receive no treatment by being given a placebo or a “sugar pill.” The use of placebos in cancer clinical trials is rare. When a placebo is used in a study, it is done with the full knowledge of the participants. Find out more about placebos in cancer clinical trials.

To join a clinical trial, patients must participate in a process known as informed consent. During informed consent, the doctor should list all of the patient’s options, so that the person understands how the new treatment differs from the standard treatment. The doctor must also list all of the risks of the new treatment, which may or may not be different from the risks of standard treatment. Finally, the doctor must explain what will be required of each patient in order to participate in the clinical trial, including the number of doctor visits, tests, and the schedule of treatment.

For specific topics being studied for eosinophilic leukemia, learn more in the Latest Research section.

Patients who participate in a clinical trial may stop participating at any time for any personal or medical reason. This may include that the new treatment is not working or there are serious side effects. Clinical trials are also closely monitored by experts who watch for any problems with each study. It is important that patients participating in a clinical trial talk with their doctor and researchers about who will be providing their treatment and care during the clinical trial, after the clinical trial ends, and/or if the patient chooses to leave the clinical trials before it ends.

Cancer.Net offers a lot of information about clinical trials in other areas of the website, including a complete section on clinical trials and places to search for clinical trials for a specific type of leukemia.

The next section helps explain the areas of research going on today about this type of leukemia. Use the menu on the side of your screen to select Latest Research, or you can select another section, to continue reading this guide.

Leukemia - Eosinophilic - Latest Research

This section has been reviewed and approved by the Cancer.Net Editorial Board, 06/2014

ON THIS PAGE: You will read about the scientific research being done now to learn more about eosinophilic leukemia and how to treat it. To see other pages, use the menu on the side of your screen.

Doctors are working to learn more about eosinophilic leukemia, ways to prevent it, how to best treat it, and how to provide the best care to people diagnosed with this disease. The following areas of research may include new options for patients through clinical trials. Always talk with your doctor about the diagnostic and treatment options best for you.

Genetic research. Because this type of disorder is usually associated with a genetic mutation, researchers are searching for specific genes or mutations that can trigger eosinophilic leukemia and which may be targeted by new drugs.

Stem cell/bone marrow transplantation. New approaches for stem cell/bone marrow transplantation (see Treatment Options) are being tested to increase the use of this treatment option.

New treatments. Better combinations of chemotherapy and other treatment combinations are also being studied, as is the drug mepolizumab. Early studies have shown that mepolizumab lowers the number of eosinophils for people with allergies and HES, and it has helped control some signs and symptoms of HES.

Supportive care. Clinical trials are underway to find better ways of reducing symptoms and side effects of current eosinophilic leukemia treatments in order to improve patients’ comfort and quality of life.

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The next section addresses how to cope with the symptoms of the disease or the side effects of its treatment. Use the menu on the side of your screen to select Coping with Side Effects, or you can select another section, to continue reading this guide.

Leukemia - Eosinophilic - Coping with Side Effects

This section has been reviewed and approved by the Cancer.Net Editorial Board, 06/2014

ON THIS PAGE: You will find out more about steps to take to help cope with physical, social, and emotional side effects. This page includes several links outside of this guide to other sections of this website. To see other pages, use the menu on the side of your screen.

Fear of treatment side effects is common after a diagnosis of eosinophilic leukemia, but it may help to know that preventing and controlling side effects is a major focus of your health care team. This is called palliative or supportive care, and it is an important part of the overall treatment plan, regardless of the stage of disease.

Common side effects from each treatment option for eosinophilic leukemia are described in detail within the Treatment Options section. Learn more about the most common side effects of leukemia and different treatments, along with ways to prevent or control them. Side effects depend on a variety of factors, including the type of leukemia, the length and dosage of treatment(s), and your overall health.

Before treatment begins, talk with your doctor about possible side effects of each type of treatment you will be receiving. Ask which side effects are most likely to happen, when they are likely to occur, and what can be done to prevent or relieve them. And, ask about the level of caregiving you may need during treatment and recovery, as family members and friends often play an important role in the care of a person with eosinophilic leukemia. Learn more about caregiving.

In addition to physical side effects, there may be emotional and social effects as well. Patients and their families are encouraged to share their feelings with a member of their health care team who can help with coping strategies, including concerns about managing the cost of your medical care

During and after treatment, be sure to tell the health care team about the side effects you experience, even if you feel they are not serious. Sometimes, side effects can last beyond the treatment period, called a long-term side effect. A side effect that occurs months or years after treatment is called a late effect. Treatment of both types of effects is an important part of survivorship care. Learn more by reading the After Treatment section or talking with your doctor.

The next section helps explain medical tests and check-ups needed after finishing treatment for leukemia. Use the menu on the side of your screen to select After Treatment, or you can select another section, to continue reading this guide.

Leukemia - Eosinophilic - After Treatment

This section has been reviewed and approved by the Cancer.Net Editorial Board, 06/2014

ON THIS PAGE: You will read about your medical care after treatment is finished and why this follow-up care is important. To see other pages, use the menu on the side of your screen.

After treatment for eosinophilic leukemia ends, talk with your doctor about developing a follow-up care plan. This plan may include regular physical examinations, blood tests, bone marrow biopsies, and possibly scans or other imaging studies to monitor your recovery for the coming months and years. People experiencing a long-term remission are encouraged to follow cancer screening recommendations for the general population.

Some eosinophilic leukemia treatments may cause the following long-term side effects. It’s important to talk with your health care team about the best ways to watch for these side effects and what will be done if they do occur.

  • Numbness, tingling, and pain in the hands and feet from vincristine.
  • A weakened heart muscle from higher total doses of doxorubicin (Adriamycin) or radiation therapy to the chest.
  • Infertility (inability to have a child) or premature menopause from high-dose cyclophosphamide or other chemotherapy. Learn more about fertility and cancer.
  • A secondary leukemia or another type of secondary cancer is more common after chemotherapy and radiation therapy.

ASCO offers treatment summary forms to help keep track of the treatment you received and develop a survivorship care plan once treatment is completed.

People recovering from eosinophilic leukemia are encouraged to follow established guidelines for good health, such as maintaining a healthy weight, not smoking, eating a balanced diet, and having recommended cancer screening tests. Talk with your doctor to develop a plan that is best for your needs. Moderate physical activity can help rebuild your strength and energy level. Your doctor can help you create an appropriate exercise plan based upon your needs, physical abilities, and fitness level. Learn more about the next steps to take in survivorship, including making positive lifestyle changes.

The next section offers a list of questions you may want to ask. Use the menu on the side of your screen to select Questions to Ask the Doctor, or you can select another section, to continue reading this guide.

Leukemia - Eosinophilic - Questions to Ask the Doctor

This section has been reviewed and approved by the Cancer.Net Editorial Board, 06/2014

ON THIS PAGE: You will find some questions to ask your doctor or other members of your health care team, to help you better understand your diagnosis, treatment plan, and overall care. To see other pages, use the menu on the side of your screen.

Talking often with the doctor is important to make informed decisions about your health care. These suggested questions are a starting point to help you learn more about your care and treatment. You are also encouraged to ask additional questions that are important to you. You may want to print this list and bring it to your next appointment, or download Cancer.Net’s free mobile app for an e-list and other interactive tools to manage your care.

  • What type of leukemia do I have?
  • Can you explain my pathology report (laboratory rest results) to me?
  • How will the disease develop? Is it possible to slow or delay this development?
  • How can my symptoms be controlled? For how long?
  • What are my treatment options?
  • What clinical trials are open to me? Where are they located, and how do I find out more about them?
  • What treatment plan do you recommend? Why?
  • What is the goal of each treatment? Is it to eliminate the leukemia, manage the symptoms and side effects, or both?
  • Who will be part of my health care team, and what does each member do?
  • Who will be coordinating my overall treatment and follow-up care?
  • What are the possible side effects of this treatment, both in the short term and the long term?
  • How will this treatment affect my daily life? Will I be able to work, exercise, and perform my usual activities?
  • Could this treatment affect my sex life? If so, how and for how long?
  • Could this treatment affect my ability to become pregnant or have children? If so, should I talk with a fertility specialist before treatment begins?
  • If I’m worried about managing the costs related to my medical care, who can help me with these concerns?
  • How can I keep myself as healthy as possible during and after treatment?
  • What follow-up tests will I need, and how often will I need them?
  • What support services are available to me? To my family?
  • Are other members of my family at risk for developing leukemia?
  • Whom should I call for questions or problems?

The next section offers some more resources that may be helpful to you. Use the menu on the side of your screen to select Additional Resources, or you can select another section, to continue reading this guide.

Leukemia - Eosinophilic - Additional Resources

This section has been reviewed and approved by the Cancer.Net Editorial Board, 06/2014

ON THIS PAGE: You will find some helpful links to other areas of Cancer.Net that provide information about cancer care and treatment. This is the final page of Cancer.Net’s Guide to Eosinophilic Leukemia. To go back and review other pages, use the menu on the side of your screen.

Cancer.Net includes many other sections about the medical and emotional aspects of leukemia, both for the person diagnosed and their family members and friends. This website is meant to be a resource for you and your loved ones from the time of diagnosis, through treatment, and beyond. Here are a few sections that may get you started in exploring the rest of Cancer.Net:

- Search for a specialist in your local area using this free database of doctors from the American Society of Clinical Oncology.

- Review dictionary articles to help understand medical phrases and terms used in medical care and treatment.

- Read more about the first steps to take when newly diagnosed with leukemia.

- Find out more about clinical trials as a treatment option.

- Learn more about coping with the emotions that leukemia can bring, including those within a family or a relationship.

- Find a national, not-for-profit advocacy organization that may offer additional information, services, and support for people with leukemia.

- Explore next steps a person can take after active treatment is complete.

This is the end of Cancer.Net’s Guide to Eosinophilic Leukemia. Use the menu on the side of your screen to select another section to continue reading this guide.