Oncologist-approved cancer information from the American Society of Clinical Oncology
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Vaginal Cancer

This section has been reviewed and approved by the Cancer.Net Editorial Board, 10/2012
Diagnosis

Doctors use many tests to diagnose cancer and find out if it has metastasized (spread). Some tests may also determine which treatments may be the most effective. For most types of cancer, a biopsy is the only way to make a definitive diagnosis of cancer. If a biopsy is not possible, the doctor may suggest other tests that will help make a diagnosis. Imaging tests may be used to find out whether the cancer has metastasized. Your doctor may consider these factors when choosing a diagnostic test:

  • Age and medical condition
  • Type of cancer suspected
  • Severity of symptoms
  • Previous test results

In addition to a physical examination, the following tests may be used to diagnose vaginal cancer:

Pelvic examination. The doctor feels the uterus, vagina, ovaries, fallopian tubes, bladder, and rectum to check for any unusual changes.

Pap test. The doctor gently scrapes the outside of the cervix and vagina and takes a sample of cells for testing. During the test, a woman will usually feel some pressure as the doctor takes the sample of the cells, but there is usually no pain.

Colposcopy. The doctor may do a colposcopy to check the vagina and cervix for any abnormalities. A colposcope is a special instrument that magnifies the cells of the cervix and vagina, similar to a microscope. The colposcope gives the doctor a lighted, magnified view of the tissues of the vagina and the cervix. The colposcope is not inserted into the woman’s body and the examination is not painful, can be done in the doctor’s office, and has no side effects. This examination can be performed on pregnant women.

Biopsy. A biopsy is the removal of a small amount of tissue for examination under a microscope. Other tests can suggest that cancer is present, but only a biopsy can make a definite diagnosis. The sample removed during the biopsy is analyzed by a pathologist (a doctor who specializes in interpreting laboratory tests and evaluating cells, tissues, and organs to diagnose disease). The type of biopsy performed will depend on the location of the tissue being biopsied.

If the biopsy indicates that a woman has vaginal cancer, the doctor will refer her to a gynecologic oncologist, a doctor who specializes in treating this type of cancer. The specialist may suggest imaging tests to see if the cancer has spread beyond the vagina.

X-ray. An x-ray is a way to create a picture of the structures inside of the body using a small amount of radiation.

Endoscopy. This test allows the doctor to see inside the body with a thin, lighted, flexible tube called an endoscope. The person may be sedated as the tube is inserted through the mouth, anus, vagina, urethra, or a small surgical opening.

Computed tomography (CT or CAT) scan. A CT scan creates a three-dimensional picture of the inside of the body with an x-ray machine. A computer then combines these images into a detailed, cross-sectional view that shows any abnormalities or tumors. Sometimes, a contrast medium (special dye) is injected into a patient’s vein to provide better detail.

Magnetic resonance imaging (MRI). An MRI uses magnetic fields, not x-rays, to produce detailed images of the body. A contrast medium may be injected into a patient’s vein to create a clearer picture.

Positron emission tomography (PET) scan. A PET scan is a way to create pictures of organs and tissues inside the body. A small amount of a radioactive substance is injected into a patient’s body. This substance is absorbed mainly by organs and tissues that use the most energy. Because cancer tends to use energy actively, it absorbs more of the radioactive substance. A scanner then detects this substance to produce images of the inside of the body.

Learn more about what to expect when having common tests, procedures, and scans.

After these diagnostic tests are done, your doctor will review all of the results with you. If the diagnosis is cancer, these results also help the doctor describe the cancer; this is called staging. Learn more about the first steps to take after a diagnosis of cancer

© 2005-2014 American Society of Clinical Oncology (ASCO). All rights reserved worldwide.

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