Childhood Cancer

Improved Care and Treatment Helps Children with Cancer Live Longer and Better

ASCO Annual Meeting
May 31, 2015

A recent analysis of information from more than 34,000 children who participated in the Childhood Cancer Survivor Study shows that modern cancer care is reducing deaths from cancer and long-term side effects. Previous research has shown that up to 18% of childhood cancer survivors die within 30 years of diagnosis. While deaths from worsening or recurrent cancers tend to slow over time, deaths from other health-related reasons, such as long-term side effects tend to increase.

Adding to Standard Treatment Increases the Number of Children Cured of Wilms Tumor

ASCO Annual Meeting
May 13, 2015

Two phase III Children’s Oncology Group studies found that using additional drugs with standard therapy lowered the chance that Wilms tumor with a specific genetic change returned after treatment. Wilms tumor is a rare type of cancer that begins in a child’s kidney. When it comes back after treatment, it is called a relapse or recurrence.

Preliminary Study Shows that the Lung Cancer Drug, Crizotinib, Is Effective for Three Childhood Cancers

ASCO Annual Meeting
May 16, 2012

In an early study with the targeted therapy drug crizotinib (Xalkori), researchers found that it stopped the growth of neuroblastoma, anaplastic large cell lymphoma (ALCL), and inflammatory myofibroblastic tumors (IMT), and in some instances, removed all signs of the cancer.

Large Study Shows Progressive Increases in Long-Term Survival for Children With Leukemia

JCO Research Round Up
March 12, 2012

A new, long-term study shows that survival rates for children and adolescents with acute lymphoblastic leukemia (ALL), the most common type of pediatric cancer, climbed steadily between 1990 and 2005. This analysis is the largest study to date of ALL survival, exploring important survival gains based on patient age, race, ethnicity, and subtype of ALL. The findings were published March 12 in the Journal of Clinical Oncology.

New High-Dose Chemotherapy Regimen Helps Children With Neuroblastoma Live Longer

ASCO Annual Meeting
June 5, 2011

A recent study showed that children with high-risk neuroblastoma who received the drugs busulphan (Busulfex, Mitosan, Myleran) and melphalan (Alkeran) lived longer than children who received the drugs carboplatin (Paraplat, Paraplatin), etoposide (Toposar, VePesid), and melphalan, a regimen called CEM. High-risk means that the neuroblastoma is likely to worsen or recur (come back after treatment). These combinations of drugs are given in high doses to kill cancer cells in the bone marrow (spongy, red tissue inside of bones).

New Chemotherapy Regimen Reduces Recurrence of ALL for Children and Young Adults

ASCO Annual Meeting
June 3, 2011

A new study shows that using high-dose methotrexate (multiple brand names) for children and young adults with a type of acute lymphoblastic leukemia (ALL) called high risk B-precursor ALL reduces the risk of recurrence when compared with the standard methotrexate regimen. Recurrence is when the ALL comes back after treatment.

Technique Enables Previously Sterile Adult Survivors of Childhood Cancer to Father Children

JCO Research Round Up
March 14, 2011

A new study has shown that a surgical technique can effectively locate and extract viable sperm in more than one-third of adult survivors of childhood cancer, who were previously considered sterile due to prior chemotherapy. Many of these men were subsequently able to have children with the help of in vitro fertilization, and the results offer a proven option for many male cancer survivors who want to be fathers but were thought infertile. 

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