Symptoms

People with mastocytosis may experience the following symptoms. Sometimes, people with mastocytosis do not show any of these symptoms. Or, these symptoms may be similar to symptoms of other medical conditions. If you are concerned about a symptom on this list, please talk with your doctor.

General symptoms:

• Hives
  
  
• Red, itchy rash
  
  
• Diarrhea
  
  
• Abdominal pain
  
  
• Fainting
  
  
• Shortness of breath
  
  
• Wheezing
  
  
• Psychologic changes (for example, irritability and inability to concentrate)

Urticaria pigmentosa:

• Tan or red-brown spots on the skin
  
  
• Abdominal pain
  
  
• Nausea
  
  
• Vomiting
  
  
• Diarrhea
  
  
• Headache
  
  
• Elevated heart rate
  
  
• Facial flushing (reddening of the face)
  
  
• Psychologic changes (for example, irritability and inability to concentrate)

Solitary mastocytoma:

• Raised or flat reddish-brown spot on the skin
  
  
• Hives
  
  
• Itching

Diffuse erythrodermic mastocytosis:

• Thickening of the skin
  
  
• Blisters

Telangiectasia macularis eruptiva perstans:

• Small lesions that do not itch

Systemic mastocytosis:

• Skin lesions
  
  
• Urticaria pigmentosa
  
  
• Facial flushing
  
  
• Itching
  
  
• Nausea
  
  
• Vomiting
  
  
• Diarrhea
  
  
• Abdominal pain
  
  
• Ulcers in the stomach and duodenum (small intestine)
  
  
• Headache
  
  
• Lightheadedness
  
  
• Heart palpitations
  
  
• Bone pain
  
  
• Anemia (low red blood cell count, which can cause fatigue)
  
  
• Psychologic changes (for example, irritability and inability to concentrate)

Symptoms of systemic mastocytosis can sometimes occur as “attacks,” where multiple symptoms appear all at once. Following the attacks, the person may feel fatigued (tired) and lethargic (drowsy, lacking energy).