Risk Factors and Prevention

A risk factor is anything that increases a person’s chance of developing cancer. Some risk factors can be controlled, such as smoking, and some cannot be controlled, such as age and family history. Although risk factors can influence the development of cancer, most do not directly cause cancer. Some people with several risk factors never develop cancer, while others with no known risk factors do. However, knowing your risk factors and communicating them to your doctor may help you make more informed lifestyle and health care choices.

Two risk factors greatly increase the risk of NPC:

Tobacco use. Use of tobacco (including cigarettes, cigars, pipes, chewing tobacco, and snuff) is the single largest risk factor for head and neck cancer. Smokers with NPC are most likely to have the squamous cell type.

Alcohol. Frequent and heavy consumption of alcohol is a risk factor for head and neck cancer.

Eighty-five percent (85%) of head and neck cancer is linked to tobacco use. Using alcohol and tobacco together increases this risk even more. However, the influence of tobacco and alcohol in the development of NPC is less than for other head and neck cancers. Recent research suggests that people who have used marijuana may be at higher risk for head and neck cancer. Secondhand smoke may also increase a person’s risk of head and neck cancer.

Other factors that can raise a person’s risk of NPC include:

Region/ancestry. NPC is most common in people who live in Southeast China and Hong Kong. When people move away from high-risk areas of the world to countries where NPC is less common, subsequent generations of their family have a gradual reduction in their inherited risk of NPC.

Epstein-Barr virus (EBV). Exposure to EBV, which is more commonly known as the virus that causes mononucleosis, plays a role in causing nasopharyngeal cancer to develop.

Gender. Men are two times more likely than women to develop NPC.

Age. NPC most commonly affects people age 30 or older. However, about half of the people with nasopharyngeal cancer in the United States are younger than 55.

Diet. Diets high in the consumption of salt-cured fish and meats increase the risk of NPC.

Environmental exposure. Extensive exposure to dust and smoke may increase the risk of NPC.

Prevention

Although some of the risk factors of NPC cannot be controlled, such as age, several can be avoided by making lifestyle changes. Stopping the use of all tobacco products is the most important thing a person can do to reduce the risk of NPC, even for people who have been smoking for many years.