People with B-cell leukemia may experience the following symptoms or signs. Sometimes, people with B-cell leukemia do not show any of these symptoms. Or, these symptoms may be caused by a medical condition that is not cancer. If you are concerned about a symptom or sign on this list, please talk with your doctor.

• Enlarged lymph nodes in PLL. In HCL, hairy cells build up more often in the spleen and bone marrow and may not cause noticeable lymph node swelling.

• Tendency to bruise easily

• Slow wound healing

• Weight loss

• Unexplained fatigue

• Persistent, unexplained abdominal pain on the left side, due to an enlarged spleen

• Frequent infections

Your doctor will ask you questions about the symptoms you are experiencing to help find out the cause of the problem, called a diagnosis [2]. This may include how long you’ve been experiencing the symptoms(s) and how often.

If leukemia is diagnosed, relieving symptoms and side effects remains an important part of care and treatment. This may also be called symptom management, palliative care, or supportive care. Be sure to talk with your health care team about symptoms you experience, including any new symptoms or a change in symptoms.