This section outlines treatments that are the standard of care (the best proven treatments available) for this specific type of leukemia. When making treatment plan decisions, patients are also encouraged to consider clinical trials as an option. A clinical trial is a research study to test a new treatment to evaluate whether it is safe, effective, and possibly better than standard treatment. Your doctor can help you review all treatment options. For more information, see the Clinical Trials  and Current Research  sections.
In cancer care, different types of doctors often work together to create a patient's overall treatment plan that combines different types of treatments. This is called a multidisciplinary team .
Treatment options and recommendations depend on several factors, including the type and stage of leukemia, possible side effects, and the patient's preferences, age, and overall health. Because CLL often develops slowly, many people may not need treatment right away, and some may never need treatment at all. Although the current standard treatments can be highly effective, it is uncertain whether any treatment can completely get rid of CLL, and most patients are not cured of the disease with treatment. The goal of treatment is to ease symptoms and long-term remission (see below). Descriptions of the most common treatment options for CLL are listed below. Learn more about making treatment decisions .
Watch and wait/active surveillance for early-stage CLL
Patients with symptoms and/or large amounts of CLL in the blood, lymph nodes, or spleen need treatment shortly after the diagnosis. For other patients, however, immediate treatment is not required, and it is recommended that the patient is monitored carefully without active treatment. During this time, the patient's blood counts are watched closely and physical examinations are performed on a regular basis. If the CLL shows signs of worsening, active treatment would then begin. Research studies have shown that no harm comes from the watch-and-wait approach (also called active surveillance or watchful waiting) when compared with immediate treatment for early-stage CLL. Some patients don't develop symptoms for years, or even decades, and will not need any treatment.
Although many patients can live comfortably with CLL without active treatment, it is beneficial to use this time to improve overall health. This includes stopping smoking  and by bringing all immunizations up to date.
Treatment is recommended for patients who develop symptoms and/or worsening blood counts. These might include increased fatigue, night sweats, enlarged lymph nodes, or lowered red blood cell or platelet counts. People with CLL are encouraged to talk with their doctor about whether their symptoms need treatment, balancing the benefits of treatment with the side effects.
Chemotherapy is the use of drugs to kill cancer cells, usually by stopping the cancer cells' ability to grow and divide. In systemic chemotherapy, the drugs travel through the bloodstream to reach cancer cells throughout the body. Chemotherapy is given by a medical oncologist, a doctor who specializes in treating cancer with medication, or a hematologist, a doctor who specializes in treating blood disorders. A chemotherapy regimen (schedule) usually consists of a specific number of cycles given over a set period of time. A patient may receive one drug at a time or combinations of different drugs at the same time.
When treatment begins, doctors may use a number of different drugs depending on the stage of the disease and the person's age and health. Chemotherapy may be given in pill form and taken orally (by mouth), intravenously (IV; through a vein), or by subcutaneous injection (an injection under the skin). Sometimes, a doctor may use a combination of drugs, but a combination of drugs is not always better than a single drug.
A standard drug that people with CLL may receive is called fludarabine (Fludara, Oforta). Similar drugs called pentostatin (Nipent) and cladribine (Leustatin) are also sometimes used to treat CLL, although fludarabine is used most commonly.
Chlorambucil (Leukeran) and cyclophosphamide (Cytoxan, Neosar) can be given orally, while cyclophosphamide can also be given intravenously. Cyclophosphamide may be given alone or with prednisone (multiple brand names), a type of oral corticosteroid.
In the past, patients initially received either fludarabine alone or chlorambucil plus prednisone, switching to the other regimen if the treatment did not work well, but more modern combinations are now recommended for initial therapy. Today, the following drugs are often given together in combinations:
- Rituximab (Rituxan) (see below) and fludarabine (sometimes abbreviated as FR)
- Cyclophosphamide and fludarabine (called FC)
- Cyclophosphamide, fludarabine and rituximab (called FCR)
- Pentostatin, cyclophosphamide, and rituximab (called PCR)
- Bendamustine (Treanda) and rituximab (a more recent combination) (called BR)
Other monoclonal antibodies (see below) that have been approved for treatment of CLL include alemtuzumab (Campath) and ofatumumab (Arzerra).
The choice of treatment often depends on the patient's age, general health, and the interest in and availability of clinical trials. Other drugs, including alvocidib (sometimes called flavopiridol), and lenalidomide (Revlimid), are being looked at as a treatment for CLL.
Learn more about chemotherapy  and preparing for treatment . The medications used to treat cancer are continually being evaluated. Talking with your doctor is often the best way to learn about the medications prescribed for you, their purpose, and their potential side effects or interactions with other medications. Learn more about your prescriptions by using searchable drug databases .
Targeted therapy is a treatment that targets the cancer's specific genes, proteins, or the tissue environment that contributes to cancer growth and survival. This type of treatment blocks the growth and spread of cancer cells while limiting damage to normal cells.
Recent studies show that not all cancers have the same targets. To find the most effective treatment, your doctor may run tests to identify the genes, proteins, and other factors in your leukemia. As a result, doctors can better match each patient with the most effective treatment whenever possible. In addition, many research studies are taking place now to find out more about specific molecular targets and new treatments directed at them. Learn more about targeted treatments .
Rituximab is a type of targeted therapy called a monoclonal antibody that is given intravenously; it binds to a protein on the surface of B cells, killing some of the CLL cells and also increasing the effect of chemotherapy. As mentioned above, rituximab is currently being used in combination with chemotherapy.
Alemtuzumab is another monoclonal antibody that has been approved by the U.S. Food and Drug Administration (FDA) as a treatment for advanced CLL when other treatments no longer work. It can be used for both T-cell and B-cell CLL. This antibody can be given either intravenously or as a subcutaneous injection. Similarly, a new antibody called ofatumumab has recently been approved when other treatments have stopped working. In addition, sometimes very high doses of steroids are used to treat patients when other medications do not work.
Side effects from chemotherapy and targeted therapy
Chemotherapy and targeted therapy can cause side effects. It's important to talk with your doctor about possible side effects for a specific medication and how they can be managed. The side effects of the common medications used to treat CLL are discussed below.
Chemotherapy for CLL may cause nausea and vomiting, although nausea and vomiting can often be prevented  with drugs. Doctors will also closely watch for decreases in normal blood counts, which can increase a person's risk of infection , bleeding , and fatigue . To manage these side effects, some patients need transfusions of red blood cells and platelets or antibiotics to treat infections.
Decreases in blood counts after chemotherapy are sometimes more severe for people with CLL than for people with other types of cancer because of the CLL cells in the bone marrow. Patients should talk with their doctors about the symptoms they might experience, how they could be prevented, and how closely they should be monitored.
Sometimes, subcutaneous injections of white blood cell growth factors such as filgrastim (Neupogen), sargramostim (Leukine), or pegfilgrastim (Neulasta) are used to help the bone marrow make normal white blood cells. Injections of epoetin (Epogen, Eprex, Procrit) or darbepoetin (Aranesp) may be given to treat anemia caused by chemotherapy. However, these drugs also have risks, and it is important for you and your doctor to carefully consider the risks and the benefits. Read more about ASCO's recommendations for when white blood cell growth factors  and epoetin and darbepoetin treatment  should be used.
Often, a person's first treatments with rituximab and alemtuzumab cause fevers and chills, which usually go away after the first few treatments.
One of the side effects of both CLL and its treatment is the risk of developing a bacterial, viral, or fungal infection. Doctors may call these opportunistic infections. In particular, patients with CLL often develop infections with herpes viruses, either as cold sores or as herpes zoster (shingles). Herpes zoster can become quite painful and turn into a severe infection. Patients should tell their doctors right away if they notice a rash or skin problems that look like blisters and are grouped together in a band across the chest or abdomen, or down one leg or arm, or on the face. These infections can be treated with antiviral drugs, and treatment works better when started sooner.
Radiation therapy is the use of high-energy x-rays or other particles to kill cancer cells. A doctor who specializes in giving radiation therapy to treat cancer is called a radiation oncologist. A radiation therapy regimen usually consists of a specific number of treatments given over a set period of time. Radiation therapy is not often used to treat CLL because the disease is located throughout the body. However, radiation therapy can be very helpful to shrink an enlarged spleen or swollen lymph nodes and relieve symptoms (see Palliative/supportive care below).
Side effects from radiation therapy may include fatigue, mild skin reactions, upset stomach, and loose bowel movements. Most side effects go away soon after treatment is finished. Learn more about radiation therapy .
Leukemia and its treatment often cause side effects. In addition to treatment to slow, stop, or eliminate the disease, an important part of care is relieving a person's symptoms and side effects. This approach is called palliative or supportive care, and it includes supporting the patient with his or her physical, emotional, and social needs.
Palliative care can help a person at any stage of illness. People often receive treatment for the leukemia and treatment to ease side effects at the same time. In fact, patients who receive both often have less severe symptoms, better quality of life, and report they are more satisfied with treatment.
Before treatment begins, talk with your health care team about the possible side effects of your specific treatment plan and supportive care options. And during and after treatment, be sure to tell your doctor or another health care team member if you are experiencing a problem, so it is addressed as quickly as possible. Learn more about palliative care .
The goal of treatment is to relieve any symptoms from CLL and to reduce the amount of remaining CLL as much as possible. A complete remission (CR) occurs when the doctor cannot find any evidence of cancer remaining after repeated testing. A partial remission (PR) is when there is some cancer remaining. A PR is most common for people with CLL who receive the current standard treatments. With a PR, patients can feel quite well with normal blood counts, have no swollen lymph nodes or spleen, but still have detectable amounts of CLL in the bone marrow.
The goal of newer, more intensive treatments is to destroy more cancer cells in the hope of prolonging a person's survival. In the future, the definition of a CR in CLL is likely to change with advances in technology. For example, some sensitive tests can find very small levels of the abnormal DNA changes specific to CLL. When these sensitive tests can no longer find any CLL, it is called a molecular remission.
A remission can be temporary or permanent. This uncertainty leads to many survivors feeling worried or anxious that the leukemia will come back. While many remissions are permanent, it's important to talk with your doctor about the possibility of the disease returning. Understanding the risk of recurrence and the treatment options may help you feel more prepared if the leukemia does return. Learn more about coping with the fear of recurrence .
When this occurs, a cycle of testing will begin again to learn as much as possible about the recurrence. After testing is done, you and your doctor will talk about your treatment options. Often the treatment plan will include the therapies described above (such as chemotherapy and targeted therapy) but may be used in a different combination or given at a different pace. Your doctor may also suggest clinical trials that are studying new ways to treat this type of recurrent leukemia.
For CLL, how long it takes for treatment to work can vary from weeks to many years, and how fast CLL grows can also vary considerably. Finding a recurrence does not mean that treatment is needed immediately. In fact, the watch-and-wait approach (see above) is usually recommended, with active treatment beginning only if the disease causes symptoms again.
People with recurrent leukemia often experience emotions such as disbelief or fear. Patients are encouraged to talk with their health care team about these feelings and ask about support services to help them cope. Learn more about dealing with cancer recurrence .
If the leukemia has not responded to treatment, the disease is called refractory CLL. Patients with this diagnosis are encouraged to talk with doctors who are experienced in treating this stage of leukemia, because there can be different opinions about the best treatment plan. Learn more about seeking a second opinion  before starting treatment, so you are comfortable with the treatment plan chosen. This discussion may include clinical trials . Supportive care will also be important to help relieve symptoms and side effects.
If CLL becomes resistant to one drug, meaning that drug no longer works, treatment with other types of drugs is recommended. Some symptoms of CLL can be treated in other ways, such as with radiation therapy or a splenectomy (surgery to remove an enlarged spleen). Some patients who have infections that keep coming back may benefit from immunoglobulin given by IV each month because patients with CLL have smaller amounts of normal antibodies. Patients who make antibodies that destroy their own blood cells (see Symptoms ) often need high doses of drugs called corticosteroids to stop the body from making these antibodies.
Stem cell transplantation/bone marrow transplantation. A stem cell transplant is a medical procedure in which diseased bone marrow is replaced by highly specialized cells, called hematopoietic stem cells. Hematopoietic stem cells are found both in the bloodstream and in the bone marrow. Today, this procedure is more commonly called a stem cell transplant, rather than bone marrow transplant, because blood stem cells are typically what is being transplanted, not the actual bone marrow tissue.
There are two types of stem cell transplantation depending on the source of the replacement blood stem cells: allogeneic (ALLO) and autologous (AUTO). ALLO is the type of transplant typically used for treating CLL and is typically considered for younger patients when the standard treatments have not worked well to treat the CLL.
In both types, the goal of transplantation is to destroy cancer cells in the marrow, blood, and other parts of the body and have replacement blood stem cells to create healthy bone marrow. In most stem cell transplants, the patient is treated with high doses of chemotherapy and/or radiation therapy to destroy as many cancer cells as possible. Learn more about bone marrow and stem cell transplantation .
For many patients, a diagnosis of refractory CLL can be very stressful and, at times, difficult to bear. Patients and their families are encouraged to talk about the way they are feeling with doctors, nurses, social workers, or other members of the health care team. It may also be helpful to talk with other patients, including through a support group.
If treatment fails
Recovery from leukemia is not always possible. If treatment is not successful, the disease may be called advanced or terminal leukemia.
This diagnosis is stressful, and it may be difficult to discuss. However, it is important to have open and honest conversations with your doctor and health care team to express your feelings, preferences, and concerns. The health care team is there to help, and many team members have special skills, experience, and knowledge to support patients and their families. Making sure a person is physically comfortable and free from pain is extremely important.
Palliative care given toward the end of a person's life is called hospice care . You and your family are encouraged to think about where you would be most comfortable: at home, in the hospital, or in a hospice environment. Nursing care and special equipment can make staying at home a workable alternative for many families. Learn more about advanced cancer care planning .
After the death of a loved one, many people need support to help cope with the loss. Learn more about grief and bereavement .
Find out more about common terms used during cancer treatment .