After treatment for CUP ends, talk with your doctor about developing a follow-up care plan. This plan may include regular physical examinations and/or medical tests to monitor your recovery for the coming months and years. ASCO offers cancer treatment summary forms  to help keep track of the cancer treatment you received and develop a survivorship care plan once treatment is completed.
Since patients with CUP are a diverse group of people and recommended treatments vary, the short-term and long-term effects of treatment are different. In addition, recommended follow-up and long-term prognosis varies from person to person. Recommendations in this section are directed primarily to patients who are in remission after successful treatment.
For patients in specific, treatable subgroups (see Treatment ) who receive treatment following guidelines for various cancers of a known primary site, the side effects and post-treatment recommendations are similar to that specific cancer. Please refer to the specific cancer type  section for more information.
For patients who receive chemotherapy and experience remission, treatment is usually stopped after four to six months. Most of the treatment-related side effects (for example, low blood counts, fatigue, weakness, and joint aches) go away within four to six weeks after treatment. However, other possible side effects such as peripheral neuropathy (numbness or discomfort in the hands and feet) improve slowly and may take six to 12 months to go away.
Close follow-up care is recommended during the first year after treatment ends, with physical examinations and routine laboratory tests every two months, and appropriate x-rays/scans every three to four months. People who were treated for CUP should tell their doctor about any new symptoms right away.
People recovering from CUP are encouraged to follow established guidelines for good health, such as maintaining a healthy weight, not smoking, eating a balanced diet, and having recommended cancer screening tests. Talk with your doctor to develop a plan that is best for your needs. Moderate physical activity can help you rebuild your strength and energy level. Your doctor can help you create an appropriate exercise plan based upon your needs, physical abilities, and fitness level. Learn more about the next steps to take in survivorship , including making positive lifestyle changes .
Find out more about common terms used after cancer treatment is complete .