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The use of epoetin and darbepoetin is one way to treat anemia caused by chemotherapy, when used according to the FDA-approved label. Treatment with one of these drugs can help patients avoid red blood cell transfusions, but it may also increase the risk of blood clots and death and may speed up tumor growth. There are other treatments that may be used for people with anemia who are receiving chemotherapy, and it is important for the doctor to rule out other causes of anemia and discuss the risks and benefits of each treatment option. Before starting treatment with epoetin or darbepoetin, your doctor should carefully discuss the risks and the benefits with you. After this conversation, you will be asked to sign a consent form indicating that you understand the risks of treatment. Be sure to talk with your doctor about any concerns you have about being treated with epoetin or darbepoetin, as well as about other ways to treat your anemia.