This section contains the latest highlighted research for patients from ASCO medical journals, including the Journal of Clinical Oncology, as well as an archive of research highlights from previous ASCO scientific meetings (2011-2015). For the latest research highlights from more recent ASCO meetings, visit the Cancer.Net Blog or check out Cancer.Net’s audio podcasts and videos for patients.
To search this archive, use the drop-down menu below. You can select a specific year, meeting or publication, and/or a specific topic, such as a type of cancer. Selecting "All" will take you to a complete list of articles that appear under all categories.
A recent analysis of information from more than 34,000 children who participated in the Childhood Cancer Survivor Study shows that modern cancer care is reducing deaths from cancer and long-term side effects.
Two phase III Children’s Oncology Group studies found that using additional drugs with standard therapy lowered the chance that Wilms tumor with a specific genetic change returned after treatment. Wilms tumor is a rare type of cancer that begins in a child’s kidney. When it comes back after treatment, it is called a relapse or recurrence.
New findings from a prospective clinical trial in children with non-hereditary retinoblastoma affecting only one eye (unilateral retinoblastoma) will help doctors identify patients who should not receive chemotherapy after surgical removal of the diseased eye.
According to a recent study, women survivors of childhood cancers who received low doses of radiation therapy aimed at the chest had a high risk of developing breast cancer at a young age. An increased risk of breast cancer is a known long-term side effect or late effect of moderate to high-dose radiation therapy to the chest. That is why the current screening recommendations for childhood cancer survivors recommend annual breast cancer screening for women who received moderate to high doses (20 or more Gray or Gy, a measure of the radiation dose) of radiation therapy to the chest. This study shows that even childhood cancer survivors who received lower doses of radiation therapy have a higher risk of breast cancer, and they may need to follow similar breast cancer screening recommendations.
In an early study with the targeted therapy drug crizotinib (Xalkori), researchers found that it stopped the growth of neuroblastoma, anaplastic large cell lymphoma (ALCL), and inflammatory myofibroblastic tumors (IMT), and in some instances, removed all signs of the cancer.
A new, long-term study shows that survival rates for children and adolescents with acute lymphoblastic leukemia (ALL), the most common type of pediatric cancer, climbed steadily between 1990 and 2005. This analysis is the largest study to date of ALL survival, exploring important survival gains based on patient age, race, ethnicity, and subtype of ALL. The findings were published March 12 in the Journal of Clinical Oncology.
A large, retrospective study has shown that children of childhood cancer survivors who received prior treatment involving radiation to testes or ovaries and/or chemotherapy with alkylating agents do not have an increased risk for birth defects compared to children of survivors who did not have such cancer treatment. Radiotherapy and chemotherapy with alkylating agents are DNA-damaging treatments, affecting both cancer and healthy cells. The findings provide reassurance that increased risks of birth defects are unlikely for cancer survivors who are concerned about the potential effects of their treatment on their children, and help guide family planning choices.
A recent study showed that children with high-risk neuroblastoma who received the drugs busulphan (Busulfex, Mitosan, Myleran) and melphalan (Alkeran) lived longer than children who received the drugs carboplatin (Paraplat, Paraplatin), etoposide (Toposar, VePesid), and melphalan, a regimen called CEM. High-risk means that the neuroblastoma is likely to worsen or recur (come back after treatment). These combinations of drugs are given in high doses to kill cancer cells in the bone marrow (spongy, red tissue inside of bones).
A new study shows that using high-dose methotrexate (multiple brand names) for children and young adults with a type of acute lymphoblastic leukemia (ALL) called high risk B-precursor ALL reduces the risk of recurrence when compared with the standard methotrexate regimen. Recurrence is when the ALL comes back after treatment.
A new study has shown that a surgical technique can effectively locate and extract viable sperm in more than one-third of adult survivors of childhood cancer, who were previously considered sterile due to prior chemotherapy. Many of these men were subsequently able to have children with the help of in vitro fertilization, and the results offer a proven option for many male cancer survivors who want to be fathers but were thought infertile.