This section contains the latest highlighted research for patients from ASCO medical journals, including the Journal of Clinical Oncology, as well as an archive of research highlights from previous ASCO scientific meetings (2011-2015). For the latest research highlights from more recent ASCO meetings, visit the Cancer.Net Blog or check out Cancer.Net’s audio podcasts and videos for patients.
To search this archive, use the drop-down menu below. You can select a specific year, meeting or publication, and/or a specific topic, such as a type of cancer. Selecting "All" will take you to a complete list of articles that appear under all categories.
In an analysis of the genes of more than 2,200 patients, researchers found that patients with specific genetic variations were more likely to develop peripheral neuropathy from chemotherapy with drugs called taxanes than patients without these changes. Peripheral neuropathy is nerve damage that causes pain and numbness. About one-third of patients who receive chemotherapy with a taxane develop neuropathy, and it can keep a patient from receiving a full dose of chemotherapy. The only other known risks of peripheral neuropathy are older age and a history of diabetes.
A large study evaluating ovarian cancer screening showed that using both a CA-125 blood test and transvaginal ultrasound to find early ovarian cancer did not reduce the risk of dying from the disease and resulted in unnecessary follow-up procedures. The CA-125 blood test measures the amount of a tumor marker called CA-125, which may be found in higher levels in women with ovarian cancer. A transvaginal ultrasound uses sound waves to create pictures of the ovaries. Both tests are used to evaluate the symptoms of ovarian cancer, its stage, and the effectiveness of treatment.
A large study of more than 12,000 Swedish men showed that first-time prostate-specific antigen (PSA) levels for men age 44 to 50 predicts the chance of developing metastatic prostate cancer (cancer that has spread to other parts of the body) or dying of the disease up to 30 years later. PSA is found in higher-than-normal levels in men with various conditions of the prostate, including prostate cancer and noncancerous conditions.
An evaluation of the lifestyle habits of more than 13,000 healthy women with a high risk of breast cancer showed that the risk of breast, lung, and colon cancers is higher for women who have smoked for a long time, compared with women who did not smoke or who smoked for a shorter time.
In a recent study, the drug cabozantinib helped manage various advanced cancers, particularly prostate, ovarian, and liver cancers. The drug also helped shrink bone metastases (cancer that has spread to the bone). Cabozantinib is a type of targeted therapy, which means it targets the cancer's specific genes, proteins, or the tissue environment that contributes to cancer growth and survival.
A new study on the use of PSA (prostate-specific antigen) testing to screen for prostate cancer found that elderly men are being screened much more frequently than men in their early fifties, even though younger men are more likely to benefit from early diagnosis and treatment. Researchers showed that men in their seventies underwent PSA screening for prostate cancer at nearly twice the rate of men in their early fifties. Men 85 and older were screened just as often.
A new study has shown that a surgical technique can effectively locate and extract viable sperm in more than one-third of adult survivors of childhood cancer, who were previously considered sterile due to prior chemotherapy. Many of these men were subsequently able to have children with the help of in vitro fertilization, and the results offer a proven option for many male cancer survivors who want to be fathers but were thought infertile.
According to an analysis of prostate cancer surgeries, surgeons need experience with robotic-assisted laparoscopic radical prostatectomy (RALP) to achieve the best results. RALP is a procedure in which a camera and instruments are inserted through small, keyhole incisions in the patient's abdomen. The surgeon then directs the robotic instruments to remove the prostate gland and surrounding tissue. It is possibly much less invasive than an open radical prostatectomy and may reduce recovery time. In general, robotic prostatectomy has less bleeding and less pain, but sexual and urinary side effects can be similar to an open radical prostatectomy.
In a large European study, researchers looked at using first-time prostate-specific antigen (PSA) levels as a way to guide future screening for prostate cancer. PSA is a protein found in higher-than-normal levels in men with prostate cancer and some noncancerous prostate conditions. Men with higher-than-normal PSA levels may be recommended for a biopsy (removal of a small piece of tissue for examination under a microscope) to look for cancer.
A new study on the drug dutasteride (Avodart) showed that it can slow the growth of early-stage prostate cancer for men whose prostate cancer is being monitored with a method called active surveillance. Active surveillance or watchful waiting is a common way to monitor prostate cancer that is growing slowly when actively treating the cancer would cause more discomfort than the disease itself. The cancer is monitored closely and active treatment begins only if the tumor shows signs of becoming more aggressive or spreading, causes pain, or blocks the urinary tract.