Research Summaries

Using the drop-down menu below, read about highlighted scientific news for patients from ASCO's Annual Meetings, Symposia, and medical journals for the past three years. You can select a specific year, meeting or publication, and/or a specific topic, such as a type of cancer. Selecting "All" will take you to a complete list of articles that appear under all categories.

This includes ASCO’s Journal of Clinical Oncology and its scientific meetings, including the ASCO Annual Meeting, a five-day meeting held each May/June. To read the Annual Meeting summaries compiled into a yearly newsletter, you can also review Research Round Up: News for Patients from the ASCO Annual Meeting.Don’t forget to check out audio podcasts and videos about this news, as well. And a list of upcoming Symposia can be found here. And, in addition to the highlighted studies below, thousands of scientific abstracts are released each year at different ASCO meetings. To search the entire collection of meeting abstracts, visit ASCO's website.

May 16, 2012

In an early study with the targeted therapy drug crizotinib (Xalkori), researchers found that it stopped the growth of neuroblastoma, anaplastic large cell lymphoma (ALCL), and inflammatory myofibroblastic tumors (IMT), and in some instances, removed all signs of the cancer.

May 16, 2012

A recent study showed that the drug olanzapine (Zyprexa) helps manage nausea and vomiting from chemotherapy when the usual treatments for these side effects are not working. Nausea and vomiting is a common, but often manageable, side effect of chemotherapy. However, despite treatments given to prevent nausea and vomiting, about 30% to 40% of patients taking certain types of chemotherapy still have nausea and vomiting. When this happens, it is called breakthrough nausea and vomiting.

May 16, 2012

About one-third of men with localized, high-risk prostate cancer who received the drug abiraterone (Zytiga) along with hormone therapy before surgery had little to no cancer remaining after six months of treatment, according to a recent clinical trial. Prostate cancer is called localized high-risk prostate cancer when the tumor has grown throughout the prostate, is high grade (meaning the cancer cells barely look like normal cells, called a Gleason score of 8), and the man has a prostate-specific antigen (PSA) level higher than 20.

March 12, 2012

A new, long-term study shows that survival rates for children and adolescents with acute lymphoblastic leukemia (ALL), the most common type of pediatric cancer, climbed steadily between 1990 and 2005. This analysis is the largest study to date of ALL survival, exploring important survival gains based on patient age, race, ethnicity, and subtype of ALL. The findings were published March 12 in the Journal of Clinical Oncology.

February 27, 2012

A new study published online February 27, 2012 in the Journal of Clinical Oncology suggests that breast cancer survivors who were treated with a common chemotherapy regimen between 1976 and 1995 show worse cognitive performance than women of the same age who never had cancer. The differences emerged mainly in the domains of learning, memory, information processing speed and psychomotor speed. This is the first study to show that such problems, which are known to occur shortly after treatment, may also be present even 20 years after treatment.

February 13, 2012

Lynch syndrome is an inherited condition of cancer predisposition caused by mutations in certain genes involved in repairing DNA damage, called “mismatch repair” genes. A new study published in the Journal of Clinical Oncology provides a new, clearer picture of the cancer risks that carriers of these mutations face, which could ultimately help guide future screening efforts to detect these cancers at an early stage.

January 31, 2012

A new drug was shown to help men with metastatic prostate cancer live longer in a recent clinical trial. Metastatic prostate cancer is cancer that has spread outside the prostate and is often difficult to treat. The drug called MDV3100 was designed to prevent male sex hormones called androgens, such as testosterone, from helping the cancer grow and spread.

January 31, 2012

A new, large study shows that intensity modulated radiation therapy (IMRT) is better than conventional conformal radiation therapy (CRT) at reducing side effects and prostate cancer recurrences (cancer that comes back after treatment) and it is less expensive than CRT and proton therapy. Both IMRT and CRT are types of radiation therapy that are designed to aim beams of radiation directly at a tumor. IMRT is better than CRT at varying the strength of the radiation so the tumor gets more radiation and the healthy tissue gets less. Proton therapy is a type of radiation therapy that uses protons instead of x-rays to treat cancer.

January 31, 2012

A new study showed that men with early-stage prostate cancer who exercise vigorously at least three hours a week have genes that are expressed differently in the prostate than those who do not exercise as intensely. Genes are small individual collections of information within each cell of the human body. How these genes affect the body is called gene expression.

January 31, 2012

The researchers found that a little more than 7% of men who received external-beam radiation therapy experienced side effects, such as narrowing of the urethra and bleeding in the bladder, compared with a little less than 7% of men who received a prostatectomy and about 3% of men who had brachytherapy. In addition, men who had external-beam radiation therapy were much more likely to experience gastrointestinal side effects, such as bleeding from the rectum. The researchers also found that external-beam radiation therapy was more than twice as expensive as brachytherapy or prostatectomy.

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