Using the drop-down menu below, read about highlighted scientific news for patients from ASCO's Annual Meetings, Symposia, and medical journals for the past three years. You can select a specific year, meeting or publication, and/or a specific topic, such as a type of cancer. Selecting "All" will take you to a complete list of articles that appear under all categories.
This includes ASCO’s Journal of Clinical Oncology and its scientific meetings, including the ASCO Annual Meeting, a five-day meeting held each May/June. To read the Annual Meeting summaries compiled into a yearly newsletter, you can also review Research Round Up: News for Patients from the ASCO Annual Meeting. Don’t forget to check out audio podcasts and videos about this news, as well. And a list of upcoming Symposia can be found here. And, in addition to the highlighted studies below, thousands of scientific abstracts are released each year at different ASCO meetings. To search the entire collection of meeting abstracts, visit ASCO's website.
In an early study with the targeted therapy drug crizotinib (Xalkori), researchers found that it stopped the growth of neuroblastoma, anaplastic large cell lymphoma (ALCL), and inflammatory myofibroblastic tumors (IMT), and in some instances, removed all signs of the cancer.
A small analysis of a larger study showed that combining two different targeted therapy drugs, dabrafenib and trametinib, stopped advanced melanoma from worsening while causing less severe side effects than the current standard targeted therapy drug. Targeted therapy is a treatment that targets a cancer's specific genes, proteins, or the tissue environment that contributes to cancer growth and survival. Specifically, dabrafenib targets changes in the BRAF gene, and trametinib targets changes in the MEK gene to stop melanoma growth.
A new analysis of a large survey showed that many primary care providers (PCPs) are not familiar with the long-term side effects of four types of chemotherapy commonly used to treat breast and colorectal cancers. It is important for cancer survivors to have lifelong follow-up care to watch for long-term side effects (also called late effects), and survivors often visit PCPs for ongoing follow-up care after cancer treatment ends. This study highlights the importance of communication between oncologists, PCPs, and cancer survivors to make sure survivors receive appropriate follow-up care and treatment for any long-term side effects.
A new, long-term study shows that survival rates for children and adolescents with acute lymphoblastic leukemia (ALL), the most common type of pediatric cancer, climbed steadily between 1990 and 2005. This analysis is the largest study to date of ALL survival, exploring important survival gains based on patient age, race, ethnicity, and subtype of ALL. The findings were published March 12 in the Journal of Clinical Oncology.
A new study published online February 27, 2012 in the Journal of Clinical Oncology suggests that breast cancer survivors who were treated with a common chemotherapy regimen between 1976 and 1995 show worse cognitive performance than women of the same age who never had cancer. The differences emerged mainly in the domains of learning, memory, information processing speed and psychomotor speed. This is the first study to show that such problems, which are known to occur shortly after treatment, may also be present even 20 years after treatment.
Lynch syndrome is an inherited condition of cancer predisposition caused by mutations in certain genes involved in repairing DNA damage, called “mismatch repair” genes. A new study published in the Journal of Clinical Oncology provides a new, clearer picture of the cancer risks that carriers of these mutations face, which could ultimately help guide future screening efforts to detect these cancers at an early stage.
A new clinical trial showed that the drug called radium-223 chloride (Ra-223), designed to treat bone metastases (cancer that has spread to the bone), helps men with metastatic castration-resistant prostate cancer live longer and slows the development of bone problems from the cancer. Castration-resistant prostate cancer is when the cancer continues to grow and spread without needing the male sex hormone testosterone.
A new, large study shows that intensity modulated radiation therapy (IMRT) is better than conventional conformal radiation therapy (CRT) at reducing side effects and prostate cancer recurrences (cancer that comes back after treatment) and it is less expensive than CRT and proton therapy. Both IMRT and CRT are types of radiation therapy that are designed to aim beams of radiation directly at a tumor. IMRT is better than CRT at varying the strength of the radiation so the tumor gets more radiation and the healthy tissue gets less. Proton therapy is a type of radiation therapy that uses protons instead of x-rays to treat cancer.
The researchers found that a little more than 7% of men who received external-beam radiation therapy experienced side effects, such as narrowing of the urethra and bleeding in the bladder, compared with a little less than 7% of men who received a prostatectomy and about 3% of men who had brachytherapy. In addition, men who had external-beam radiation therapy were much more likely to experience gastrointestinal side effects, such as bleeding from the rectum. The researchers also found that external-beam radiation therapy was more than twice as expensive as brachytherapy or prostatectomy.
A new study showed that men with early-stage prostate cancer who exercise vigorously at least three hours a week have genes that are expressed differently in the prostate than those who do not exercise as intensely. Genes are small individual collections of information within each cell of the human body. How these genes affect the body is called gene expression.