In the annual Research Round Up podcast series, Cancer.Net Associate Editors answer the question, “What was the most exciting or practice-changing research in your field presented at the ASCO20 Virtual Scientific Program?” In this final episode of 2020, 2 editors discuss a range of research presented in central nervous system (CNS) tumors and lymphoma.
Treatment advances in primary and secondary brain tumors
Dr. Glenn Lesser, the 2020 Cancer.Net Associate Editor for Central Nervous System Tumors, discusses new research in cancer that has started in the brain or spinal cord, as well as cancer that has spread to the brain from another part of the body, called secondary or metastatic cancer.
First, he discusses a study on whether adding low-dose whole-brain radiation therapy to standard chemotherapy helps people with a specific type of non-Hodgkin lymphoma called primary CNS lymphoma live longer. [4:24] He also discusses a study that looked at whether adding a targeted therapy called tucatinib (Tukysa) to chemotherapy could treat HER2-positive breast cancer that has spread to the brain. [7:47]
New research in different types of lymphoma
Dr. Michael Williams, the 2020 Cancer.Net Associate Editor for Lymphoma, discusses 3 studies across the field of lymphoma. First, he discusses a study that compared the immunotherapy drug pembrolizumab (Keytruda) with a standard treatment for Hodgkin lymphoma that was resistant to the initial treatment, called refractory, or if it came back after treatment, called recurrent or relapsed. [13:58] Next, he discusses a study comparing 2 targeted therapy drugs, ibrutinib (Imbruvica) and zanubrutinib (Brukinsa), for people with a specific type of non-Hodgkin lymphoma known as Waldenstrom macroglobulinemia (lymphoplasmacytic lymphoma). [16:32] Finally, he discusses a study that looked at treating people with refractory or recurrent follicular lymphoma with a chimeric antigen receptor (CAR) T-cell therapy called axicabtagene ciloleucel (Yescarta). [19:09]
Disclosure information for this podcast’s speakers can be found in their individual biographies, which are linked to in the paragraphs above.
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