Clinical trials are the main way that doctors are able to find better treatment for diseases like cancer. Active clinical trials are exploring possible new cancer treatments and ways to prevent or reduce side effects. In this podcast series, members of the Cancer.Net Editorial Board share their expert opinions about ongoing clinical trials that are studying genitourinary (GU) cancers.
In this podcast, Timothy Gilligan, MD, FASCO, leads a discussion with Neeraj Agarwal, MD; Brian Shuch, MD; and Tian Zhang, MD, about 3 clinical trials in prostate cancer, bladder cancer, and kidney cancer.
The MAGNITUDE phase III clinical trial is testing whether treating metastatic castrate-resistant prostate cancer with the PARP inhibitor drug niraparib (Zejula) in combination with abiraterone (Zytiga) delays cancer growth and helps patients live longer. [3:33]
The PROOF 302 phase III clinical trial is studying whether using the FGFR inhibitor drug infigratinib (BGJ398) after surgery for people with high-risk bladder cancer helps prevent the cancer from recurring. [13:24]
The CYTOSHRINK phase II clinical trial is examining whether treating people with metastatic kidney cancer who haven’t received previous treatment using stereotactic body radiation therapy (SBRT) along with standard treatment with immunotherapy delays cancer growth. [20:18]
Dr. Gilligan is a medical oncologist at the Cleveland Clinic Taussig Cancer Institute and a Cancer.Net Specialty Editor for Genitourinary Cancers. Dr. Agarwal directs the Genitourinary Oncology Program at the Huntsman Cancer Institute at the University of Utah and is a Cancer.Net Specialty Editor for Genitourinary Cancers. Dr. Shuch is the director of the Kidney Cancer Program at UCLA Health, the Alvin & Carrie Meinhardt Endowed Chair in Kidney Cancer Research at the institution, and a Cancer.Net Specialty Editor for Genitourinary Cancers. Dr. Zhang is an assistant professor of medicine at Duke University School of Medicine, a medical oncologist at Duke Cancer Institute, and a Cancer.Net Specialty Editor for Genitourinary Cancers.
Disclosure information for this podcast’s speakers can be found in their individual biographies, which are linked in the paragraph above.
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