ON THIS PAGE: You will find some basic information about this disease and the parts of the body it may affect. This is the first page of Cancer.Net’s Guide to Inflammatory Breast Cancer. Use the menu to see other pages. Think of that menu as a roadmap for this entire guide.
About the breast
The breast is made up of different tissue, ranging from very fatty tissue to very dense tissue. Within this tissue is a network of lobes. The lobes are made up of tiny, tube-like structures called lobules that contain milk glands. Tiny ducts connect the glands, lobules, and lobes. These ducts carry the milk from the lobes to the nipple, located in the middle of the areola. The areola is the darker area that surrounds the nipple. Blood and lymph vessels also run throughout the breast. Blood nourishes the cells, and the lymph system drains bodily waste products. The lymph vessels connect to lymph nodes, the small, bean-shaped organs that help fight infection.
About inflammatory breast cancer
Cancer begins when healthy cells in the breast change and grow out of control, forming a mass or sheet of cells called a tumor. A tumor can be cancerous or benign. A cancerous tumor is malignant, meaning it can grow and spread to other parts of the body. A benign tumor means the tumor can grow but will not spread. Breast cancer spreads when the cancer grows into other parts of the body or when breast cancer cells move to other parts of the body through the blood vessels and/or lymph vessels. This is called metastasis.
Inflammatory breast cancer is a less common form of breast cancer. The cancer gets its name because it causes symptoms that are similar to a breast infection. These symptoms include redness, tenderness, swelling, and pain in the breast. However, unlike an infection, inflammatory breast cancer does not improve with antibiotic treatment.
In inflammatory breast cancer, the cancer cells enter and block the lymph vessels within the breast. This blockage can cause the breast and its skin to swell up because the lymph fluid cannot leave. It can also cause the breast to look red and inflamed. Inflammatory breast cancer often grows quickly and has a higher risk of spreading than other types of breast cancer. This means that treatment often needs to be started quickly and requires a team approach by doctors. Treatment usually includes a combination of chemotherapy, surgery, radiation therapy, and possibly hormonal, or endocrine, therapy. These treatments are explained in the Types of Treatment section.
Breast cancer subtypes
Breast cancer is not a single disease, even among the same type of breast cancer. When you are diagnosed with breast cancer, your doctor will recommend doing lab tests on the cancerous tissue. These tests help your doctor find out more about cancer and choose the most effective treatment.
Testing can determine if the cancer is hormone receptor positive or negative, human epidermal growth factor receptor 2 (HER2) positive or negative, or triple negative. These terms are explained below:
Hormone receptor positive or negative. Breast cancers expressing estrogen receptors (ER) and progesterone receptors (PR) are called “hormone receptor positive.” These cancers may depend on the hormones estrogen and/or progesterone to grow. A breast cancer that does not have estrogen and progesterone receptors is called “hormone receptor negative.”
HER2 positive or negative. About 10% to 20% of breast cancers depend on the gene called human epidermal growth factor receptor 2 (HER2) to grow. These cancers are called “HER2 positive” and have too many HER2 receptors and/or extra copies of the HER2 gene. The HER2 gene makes a protein that is found on the cancer cell and is important for tumor cell growth. A breast cancer that does not have excessive numbers of HER2 receptors or copies of the HER2 gene is called “HER2 negative.”
Triple negative. If a breast tumor does not express ER, PR, and/or HER2, it is called “triple negative.” This type of breast cancer may grow more quickly than hormone receptor-positive disease, and chemotherapy may work better as a treatment. About 20% of inflammatory breast cancers are triple negative.
Looking for More of an Introduction?
If you would like more of an introduction to breast cancer, explore these related items. Please note that these links will take you to other sections on Cancer.Net:
ASCO Answers Fact Sheet: Read a 1-page fact sheet that offers an introduction to breast cancer. This free fact sheet is available as a PDF, so it is easy to print.
ASCO Answers Guide: Get this free 52-page booklet that helps you better understand breast cancer and treatment options. The booklet is available as a PDF, so it is easy to print.
The next section in this guide is Statistics. It helps explain the number of people who are diagnosed with inflammatory breast cancer and general survival rates. Use the menu to choose a different section to read in this guide.