Carcinoid Tumor: Symptoms and Signs

Approved by the Cancer.Net Editorial Board, 10/2017

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A carcinoid tumor often causes no symptoms in its early stages. They are usually found by a surgeon during an unrelated surgery or on x-rays for another condition. Below you will find possible signs and symptoms of a GI carcinoid tumor, lung carcinoid tumor, carcinoid syndrome, and carcinoid crisis. However, the cause of a symptom may be a different medical condition that is not a carcinoid tumor.

If you are concerned about any changes you experience, please talk with your doctor. Your doctor will ask how long and how often you’ve been experiencing the symptom(s), in addition to other questions. This is to help figure out the cause of the problem, called a diagnosis.

Symptoms of a GI carcinoid tumor

GI carcinoid tumors are the type most likely to cause symptoms. However, symptoms of a GI carcinoid tumor may only appear if the tumor spreads to the liver. In this situation, a hormone-like substance produced by the tumor can travel throughout the body and cause carcinoid syndrome (see below).

People with a GI carcinoid tumor may experience the following symptoms or signs:

  • Facial flushing, which is redness and a warm feeling over the face

  • Diarrhea

  • Abdominal pain caused by blockage of the intestines

  • Asthma

  • Rash

  • Heart disease

  • Intestinal bleeding

  • Pellagra, which causes scale-like skin sores, diarrhea, and mental disturbances

  • Melena, which are dark, tarry stools that contain blood. They usually indicate there is bleeding somewhere in the GI tract.

Symptoms of a lung carcinoid tumor

A carcinoid tumor in the lung causes symptoms that result from hormones bypassing the liver and entering the bloodstream. However, a lung carcinoid tumor is far less likely to cause carcinoid syndrome (see below) than a GI carcinoid tumor.

People with a lung carcinoid tumor may experience the following symptoms or signs:

  • Cough, with or without bloody sputum or phlegm

  • Wheezing

  • Post-obstructive pneumonia, which is when a tumor blocking a large air passage causes an infection

Carcinoid syndrome

Carcinoid syndrome is more common in people who have had a carcinoid tumor for many years. Around 60% of people with a carcinoid tumor eventually develop carcinoid syndrome.

People with carcinoid syndrome may experience the following symptoms or signs:

  • Facial flushing

  • Sweating

  • Diarrhea

  • Shortness of breath

  • Wheezing or asthma-like symptoms

  • Fast heartbeat

  • Heart murmur

  • Unexplained weight gain

  • Weakness

  • Secondary diabetes

  • Increased body and facial hair

  • High blood pressure and significant fluctuations in blood pressure

  • Neurosis and psychosis. Neurosis is a psychological or behavioral disorder primarily characterized by anxiety. Psychosis is a severe emotional and behavioral disorder that can cause a person’s mental capacity to become very distorted or disorganized, which may interfere with the person’s ability to cope with the demands of everyday life.

Stress, strenuous exercise, and drinking alcohol may make these symptoms worse.

Carcinoid crisis

Carcinoid crisis is a term used when all of the symptoms of carcinoid syndrome occur at the same time. Carcinoid crisis is the most serious and life-threatening complication of carcinoid syndrome. It generally occurs after a person has already experienced some symptoms of carcinoid syndrome.

Carcinoid crisis may occur suddenly, or it can be brought on by stress, chemotherapy, or anesthesia. A carcinoid crisis may be prevented and successfully treated with octreotide (Sandostatin), a medication that helps raise low blood pressure and control the production of hormones.

Managing symptoms

If a carcinoid tumor is diagnosed, relieving symptoms remains an important part of cancer care and treatment. This may also be called symptom management, palliative care, or supportive care. Below are some common symptoms of a carcinoid tumor, followed by information on how each can be managed. Be sure to talk with your health care team about the symptoms you experience, including any new symptoms or a change in symptoms.

  • Facial flushing. Avoid stress. Ask your doctor about specific substances and foods, including alcohol, that cause facial flushing so you can avoid them.

  • Wheezing. Ask your doctor about the use of a bronchodilator, a medication that relaxes the muscles in the lungs to make breathing easier.

  • Diarrhea. Ask your doctor about the use of anti-diarrheal medications.

  • Carcinoid syndrome. Ask your doctor about the use of octreotide, which is the most effective single medication to treat carcinoid syndrome.

  • Heart problems. Tell your doctor immediately if you think you may have a problem with your heart, and ask about the use of diuretics. Diuretics are drugs that lower blood pressure by helping the body get rid of water and sodium.

Learn more about managing common cancer symptoms and treatment side effects.

The next section in this guide is Diagnosis. It explains what tests may be needed to learn more about the cause of the symptoms. You may use the menu to choose a different section to read in this guide.