Leukemia - Acute Myeloid - AML - Childhood: Introduction

Approved by the Cancer.Net Editorial Board, 12/2017

ON THIS PAGE: You will find some basic information about this disease and the parts of the body it may affect. This is the first page of Cancer.Net’s Guide to Childhood Acute Myeloid Leukemia (AML). Use the menu to see other pages. Think of that menu as a roadmap for this complete guide.

Leukemia is a cancer of the blood. It begins when healthy blood cells change and grow out of control. Acute myeloid leukemia (AML) is a type of leukemia that is a cancer of the blood-forming tissue in the bone marrow, the spongy tissue inside your bones. AML may also be called acute nonlymphocytic leukemia or acute myelogenous leukemia.

About bone marrow and blood cells

Bone marrow is the spongy, red tissue in the inner part of the large bones. It is where a person’s blood cells are made. Healthy immature blood cells are called blasts. Blasts mature into one of 3 different types of blood cells:

  • White blood cells, which fight infection in the body

  • Red blood cells, which carry oxygen and other nutrients throughout the body

  • Platelets, which help the blood to clot

About AML

In AML, the bone marrow makes many abnormal cancerous cells, also called blasts or myeloblasts because they look similar to healthy immature blast cells. Instead of becoming healthy mature blood cells, cancerous cells divide rapidly and out of control. The cancerous cells are unable to mature and work like healthy blast cells, and they do not die easily.

Eventually, these myeloblasts fill up the bone marrow, preventing healthy cells from being made, and then build up in the bloodstream. They can also move into the lymph nodes, brain, skin, liver, kidneys, ovaries (in girls), testicles (in boys), and other organs. AML cells occasionally form a solid mass or tumor, called a chloroma.

Both children and adults can develop leukemia. This section is about AML that occurs in children, sometimes called pediatric AML. Learn more about AML in adults.

Looking for More of an Introduction?

If you would like more of an introduction, explore these related items. Please note that these links will take you to other sections on Cancer.Net:

  • Cancer.Net Patient Education Videos: View short videos led by ASCO experts in childhood cancer and leukemia that provide basic information and areas of research.

The next section in this guide is Statistics. It helps explain the number of people who are diagnosed with this disease and general survival rates. You may use the menu to choose a different section to read in this guide.