Lymphoma - Non-Hodgkin - Childhood: Latest Research

Approved by the Cancer.Net Editorial Board, 01/2020

ON THIS PAGE: You will read about the scientific research being done to learn more about childhood non-Hodgkin lymphoma and how to treat it. Use the menu to see other pages.

Doctors are working to learn more about childhood NHL, ways to prevent it, how to best treat it, and how to provide the best care to children and teens diagnosed with non-Hodgkin lymphoma. The following areas of research may include new options for patients through clinical trialsAlways talk with your child’s doctor about the best diagnostic and treatment options for your child.

  • Genetics. One of the most important areas of research involves learning more about the genetic predisposition to developing childhood NHL and about how well genetic subtypes of NHL will respond to different treatments.

  • Immunotherapy. As explained in the Types of Treatment section, immunotherapy (also called biologic therapy) is designed to boost the body’s natural defenses to fight the cancer. Research for NHL is investigating the use of monoclonal antibodies designed to destroy lymphoma cells that make a specific protein and spare normal cells from the toxic effects of chemotherapy.

  • Targeted therapy. As explained in the Types of Treatmenttargeted therapy is a treatment that targets the cancer’s specific genes, proteins, or the tissue environment that contributes to cancer growth and survival. For NHL, researchers are continuing to investigate specific drugs that affect the regulation of the lymphoma cell, while limiting damage to normal cells.

  • Expanded use of bone marrow/stem cell transplantation. Research in this field is investigating giving reduced intensity conditioning therapy (lower doses of chemotherapy and radiation therapy, aiming to reduce complications following a transplantation) followed by an allogeneic stem cell transplantation for children with recurrent NHL.

  • Palliative care/supportive care. Clinical trials are underway to find better ways of reducing symptoms and side effects of current NHL treatments to improve comfort and quality of life for patients.

Looking for More About Latest Research?

If you would like additional information about the latest areas of research regarding NHL, explore these related items that take you outside of this guide:

  • Visit the website of Conquer Cancer, the ASCO Foundation to find out how to help support cancer research. Please note that this link takes you to a separate ASCO website. 

The next section in this guide is Coping with TreatmentIt offers some guidance on how to cope with the physical, emotional, social, and financial changes that NHL and its treatment can bring. Use the menu to choose a different section to read in this guide.