ON THIS PAGE: You will find some basic information about this disease and the parts of the body it may affect. This is the first page of Cancer.Net’s Guide to Uterine Cancer. Use the menu to see other pages. Think of that menu as a roadmap for this entire guide.
About the uterus
The pear-shaped uterus is hollow and located in the pelvis between the bladder and rectum. It is the largest organ of the female reproductive system. The uterus is also called the womb. It is where a baby grows during pregnancy. The uterus has 3 sections:
The cervix, which is the narrow lower section
The isthmus, which is the broad section in the middle
The fundus, which is the dome-shaped top section
The uterus is made up of 3 layers: the endometrium (inner layer), the myometrium (the thickest layer composed almost entirely of muscle), and the serosa (the thin outer lining of the uterus).
During a person's childbearing years, the ovaries typically release an egg every month, and the endometrium grows and thickens in preparation for pregnancy. If the person does not get pregnant, this endometrial lining sheds through the vagina, a process known as menstruation. This process continues until menopause, when the ovaries stop releasing eggs and producing female hormones.
About uterine cancer
Uterine cancer is the most common cancer occurring within the female reproductive system. Uterine cancer begins when healthy cells in the uterus change and grow out of control, forming a mass called a tumor. A tumor can be cancerous or benign. A cancerous tumor is malignant, meaning it can grow and spread to other parts of the body. A benign tumor can grow but generally will not spread to other body parts.
Noncancerous conditions of the uterus include:
Fibroids: Benign tumors in the muscle of the uterus
Benign polyps: Abnormal growths in the lining of the uterus
Endometriosis: A condition in which endometrial tissue, which usually lines the inside of the uterus, is found on the outside of the uterus or other organs
Endometrial hyperplasia: A condition in which there is an increased number of cells and glandular structures in the uterine lining. Endometrial hyperplasia can have either normal or atypical cells and simple or complex glandular structures. The risk for developing cancer in the lining of the uterus is higher when endometrial hyperplasia has atypical cells and complex glands.
There are 2 major types of uterine cancer:
Adenocarcinoma. This type makes up the majority of uterine cancers. It develops from cells in the endometrium. This cancer is commonly called endometrial cancer. One common endometrial adenocarcinoma subtype is called endometrioid carcinoma. Treatment for this type of cancer varies depending on the grade of the tumor, how far it goes into the uterus, and the stage or extent of the disease (see Stages and Grades). Less common subtypes of uterine adenocarcinomas include serous, clear cell, and carcinosarcoma. Carcinosarcoma is a mixture of adenocarcinoma and sarcoma (see below).
Sarcoma. This type of uterine cancer develops in the supporting tissues of the uterine glands or in the myometrium, which is the uterine muscle. Sarcoma accounts for about 2% to 4% of uterine cancers. Subtypes of endometrial sarcoma include leiomyosarcoma, endometrial stromal sarcoma, and undifferentiated sarcoma. Learn more about sarcoma.
Cancer confined to the uterine cervix is treated differently from uterine cancer. Learn more about cervical cancer in a separate guide on this website. The rest of this section covers the more common endometrial (adenocarcinoma) cancer.
About genetics and family history of uterine cancer
A higher risk for uterine cancer can be inherited, meaning it is passed from generation to generation, or it may skip a generation to appear in the next. This happens in about 5% of uterine cancer cases. The syndrome most commonly associated with inherited uterine cancer is called Lynch syndrome. Lynch syndrome is also associated with several other types of cancer, including types of colon, kidney, bladder, and ovarian cancers.
Cancer can be screened for signs of Lynch syndrome, which can then be confirmed with genetic testing. If a person is found to have Lynch syndrome, family members may wish to be tested, too. People affected by Lynch syndrome should tell their doctors so they can receive increased screening for Lynch-associated cancers, such as more frequent colonoscopies. Other family members may consider preventive surgery for uterine and ovarian cancers.
It is recommended that all patients with endometrial cancer have their cancer screened for Lynch syndrome. Ask your doctor if you need additional testing, including for other possible inherited conditions. Learn more about Lynch syndrome and genetic testing in other sections of this website.
Looking for More of an Introduction?
If you would like more of an introduction, explore these related items. Please note that these links will take you to other sections on Cancer.Net:
ASCO Answers Fact Sheet: Read a 1-page fact sheet that offers an introduction to uterine cancer. This free fact sheet is available as a PDF, so it is easy to print.
The next section in this guide is Statistics. It helps explain the number of people who are diagnosed with uterine cancer and general survival rates. Use the menu to choose a different section to read in this guide.