Liver Cancer: Statistics

Approved by the Cancer.Net Editorial Board, 05/2022

ON THIS PAGE: You will find information about the number of people who are diagnosed with liver cancer each year. You will also read general information on surviving the disease. Remember, survival rates depend on several factors. Use the menu to see other pages.

This year, an estimated 41,260 adults (28,600 men and 12,660 women) in the United States will be diagnosed with primary liver cancer. From 1980 to 2015, the incidence of liver cancer more than tripled. However, the rate has stabilized recently. Between 2013 and 2017, incidence rates in women increased by approximately 2% annually, while remaining steady in men. However, men are almost 3 times more likely than women to be diagnosed with the disease. Worldwide, an estimated 905,677 people were diagnosed with liver cancer in 2020.

It is estimated that 30,520 deaths (20,420 men and 10,100 women) from this disease will occur in the United States this year. For men, liver cancer is the fifth most common cause of cancer death. It is the seventh most common cause of cancer death among women. The overall liver cancer death rate more than doubled between 1980 and 2013, but it stabilized through 2019. Between 2014 and 2018, the liver cancer death rate in women increased by 1% annually but remained steady in men.

Worldwide, liver cancer is the third leading cause of cancer death. In 2020, an estimated 830,180 people around the world died from the disease. When compared with the United States, liver cancer is much more common in sub-Saharan Africa and Southeast Asia. In some countries, it is the most common cancer type.

The 5-year survival rate tells you what percent of people live at least 5 years after the cancer is found. Percent means how many out of 100. The general 5-year survival rate for liver cancer in the United States is 20%, compared to 3% 40 years ago. Survival rates depend on several factors, including the stage of the disease.

For the 43% of people who are diagnosed with liver cancer at an early stage, the 5-year survival rate is 35%. If the cancer has spread to surrounding tissues or organs and/or to the regional lymph nodes, the 5-year survival rate is 12%. If the cancer has spread to a distant part of the body, the 5-year survival rate is 3%. However, even if the cancer is found at a more advanced stage, treatments are available to help many people with liver cancer experience a quality of life similar to that of before their diagnosis, at least for some time. If surgery is possible, it generally results in higher survival rates across all stages of the disease.

It is important to remember that statistics on the survival rates for people with liver cancer are an estimate. The estimate comes from annual data based on the number of people with this cancer in the United States. Also, experts measure the survival statistics every 5 years. This means the estimate may not reflect the results of advancements in how liver cancer is diagnosed or treated from the last 5 years. Talk with your doctor if you have any questions about this information. Learn more about understanding statistics.

Statistics adapted from the American Cancer Society's (ACS) publication, Cancer Facts & Figures 2022 and Cancer Facts & Figures 2021; the ACS website; and the International Agency for Cancer Research website. (All sources accessed January 2022.)

The next section in this guide is Medical Illustrations. It offers a drawing of the location of the liver in the body. Use the menu to choose a different section to read in this guide.