Testicular Cancer: Introduction

Approved by the Cancer.Net Editorial Board, 02/2019

ON THIS PAGE: You will find some basic information about this disease and the parts of the body it may affect. This is the first page of Cancer.Net’s Guide to Testicular Cancer. Use the menu to see other pages. Think of that menu as a roadmap for this complete guide.

Testicular cancer begins when healthy cells in a testicle change and grow out of control, forming a mass called a tumor. A cancerous tumor is malignant, meaning it can spread to other parts of the body.

Another name for testicular cancer is testis cancer.

About the testicles

The testicles are part of a man’s reproductive system. Normally, each man has 2 testicles, and they are located under the penis in a sac-like pouch called the scrotum. They can also be called testes or gonads. The testicles produce sperm and testosterone. Testosterone is a hormone that plays a role in the development of a man’s reproductive organs and other masculine characteristics.

About testicular cancer

Most types of testicular cancer develop in the sperm-producing cells known as germ cells and are referred to as germ cell tumors. Germ cell tumors in men can start in several parts of the body:

  • The testicles, which is the most common location

  • The back of the abdomen near the spine, called the retroperitoneum

  • The central portion of the chest between the lungs, called the mediastinum

  • The lower spine

  • Very rarely, a small gland in the brain called the pineal gland

Testicular cancer is almost always curable if found early, and it is usually curable even when found at a later stage.

Types of testicular cancer

There are 2 main categories of germ cell tumors that start in the testicles.

  • Seminoma. A tumor is only called a seminoma if it is 100% seminoma. This means that the cancer does not include any of the types of tumor listed below.

  • Non-seminoma. A non-seminoma contains at least 1 of the following types of tumor:

    • Choriocarcinoma

    • Embryonal carcinoma

    • Yolk sac tumor

    • Teratoma

Each of these can occur alone or in any combination. Most non-seminomas are a mix of at least 2 different subtypes of germ cell tumor. Non-seminomas may also be partly seminoma at any percentage level less than 100%. For example, a tumor that is 99% seminoma and 1% yolk sac tumor is still diagnosed and treated as a non-seminoma.

Generally, non-seminomas tend to grow and spread more quickly than seminomas, but prompt diagnosis and treatment are important for both types of tumors.

Other, less common types of testicular tumors include:

  • Leydig cell tumor

  • Sertoli cell tumor

  • Carcinoma of the rete testis, which is a part of the testicles

  • Testicular lymphoma

This article provides information only on seminoma and non-seminoma of the testicles in men who have reached puberty. Testicular cancer is uncommon in boys who have not yet reached puberty. Childhood testicular cancer that occurs before puberty is treated differently than cancer that develops after puberty in teenagers and adults.

Other types of cancer, such as lymphoma and leukemia, occasionally spread to the testicles. To find out more about cancer that started in another part of the body and spread to the testicles, read about that specific type of cancer.

Looking for More of an Introduction?

If you would like more of an introduction, explore the following item. Please note that this link will take you to another section on Cancer.Net:

  • ASCO Answers Fact Sheet: Read a 1-page fact sheet that offers an introduction to testicular cancer. This free fact sheet is available as a PDF, so it is easy to print out.

The next section in this guide is Statistics. It helps explain the number of people who are diagnosed with testicular cancer and general survival rates. Use the menu to choose a different section to read in this guide.